ID F0YH29_AURAN Unreviewed; 608 AA.
AC F0YH29;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=AURANDRAFT_30594 {ECO:0000313|EMBL:EGB05516.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB05516.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
CC -!- SIMILARITY: Belongs to the PLPL family.
CC {ECO:0000256|ARBA:ARBA00006104}.
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DR EMBL; GL833140; EGB05516.1; -; Genomic_DNA.
DR RefSeq; XP_009039650.1; XM_009041402.1.
DR AlphaFoldDB; F0YH29; -.
DR EnsemblProtists; EGB05516; EGB05516; AURANDRAFT_30594.
DR GeneID; 20220908; -.
DR KEGG; aaf:AURANDRAFT_30594; -.
DR eggNOG; KOG2214; Eukaryota.
DR InParanoid; F0YH29; -.
DR OMA; CSWFTRG; -.
DR OrthoDB; 154387at2759; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF66; TRIACYLGLYCEROL LIPASE PTL2; 1.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..395
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 608 AA; 66646 MW; A8AEA1CDFBBEF193 CRC64;
MWPRFNRVTY HILRWPILVV VYAFVFVELL FYCALRLFVA FAEFAVATPK HRELRHALRH
SKDYETWLAC ARALDSSKGV AVWQSDLRST RYNWPFVKGL IAQLREARAS DDWRAVAVAL
RLCSRPNVGG IMAPQLFSAT HTGDPKLVVT DFVEEIAASV RWLTAYALAS NDAACVSTAR
ELLGAARESY GRTVLSLSGG GALGTYHFGV VRALLTEDML PETICGTSAG SIISVFACCR
TRAELEEDLY DDAKLVRYLR CFDRSPWACV KSFLKTGHAY DGGEWMDIAK WFANDRPEGV
LNMTFAEAYA RSKKKLAITV HAKGKRAPPV LLTHLTSPHV TIVSAVVATA AVPLLIAPQV
LLEKDPETGV VAPQAGGEAY IDGSIVHDIP TVGLKEAFNA KFVVASQVNP HFQPMLYSTH
GAAGEPCRWS PSFGALSSED AWRGGFVLAA LELYLRTDMV NKLKFLADID ASPGWSGKMF
AQSFEGTITI TPRLAPVDYL NLFSNPTPGN IGRYTREGRV ATYQKMAMLR TRLSVERALN
EGCDALRPKP ALVRASSDHG FAGHGADRPR MRRLGGAGAL DWATPSTISA FPDVDADPDA
HCFDDDGL
//
