ID   F0ZFT8_DICPU            Unreviewed;       751 AA.
AC   F0ZFT8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN   ORFNames=DICPUDRAFT_46683 {ECO:0000313|EMBL:EGC37232.1};
OS   Dictyostelium purpureum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC37232.1, ECO:0000313|Proteomes:UP000001064};
RN   [1] {ECO:0000313|Proteomes:UP000001064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX   PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA   Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA   Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA   Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA   Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA   Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA   Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT   "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT   Dictyostelium purpureum.";
RL   Genome Biol. 12:R20.1-R20.23(2011).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; GL871005; EGC37232.1; -; Genomic_DNA.
DR   RefSeq; XP_003286283.1; XM_003286235.1.
DR   AlphaFoldDB; F0ZFT8; -.
DR   STRING; 5786.F0ZFT8; -.
DR   EnsemblProtists; EGC37232; EGC37232; DICPUDRAFT_46683.
DR   GeneID; 10503676; -.
DR   KEGG; dpp:DICPUDRAFT_46683; -.
DR   eggNOG; KOG2166; Eukaryota.
DR   InParanoid; F0ZFT8; -.
DR   OMA; KQLIMDP; -.
DR   OrthoDB; 7770at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001064; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0043223; C:cytoplasmic SCF ubiquitin ligase complex; IEA:EnsemblProtists.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF63; CULLIN-5; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001064}.
FT   DOMAIN          383..616
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   751 AA;  87105 MW;  CB13E1DD5DFB94AA CRC64;
     MSGDQITVDE LWQDSQPTFE DLFLDLKKGL TRKRYMEIYT KIYNYCSSAN EKALTDFYQP
     KVKQLVSEKA IQIMSRSESL PNDALLLFFR NQWNEWKMSS SVLKNLLSPV NKIHSSDKKT
     TSSSTNSSES VVYSDTLNAW RETAFTPLKN KLSVSLLSII KNDRTGDSAN LQVLSDSLEC
     YVQLGPEKNK LEIYQSCFEN QFLSETETFY KVESQDFIEK NGVSEYMRHV YNRISQETNR
     VNKYMPISTL DKLTKILNSV LISNYKDQFA NKFLDILIED KSADLAMMYS LLNRVNYLLP
     LRVTFSDFIR SEGLKEIESN LKEAQEKPQV LISILLKVYS RFNIMIKECY NNDTDFTTAM
     DKSFTNLVNE NPASFDPKKK ESTIPVVLSK FCDQILRKGP YHISDETELE QKLTEAVCLF
     RYLPDKDIFM LNYQKMLSKR LVEDISASED AETLMINKLK NHQGFDYCTK LTRMITDMRL
     CKDINTNFQN HLNEKNLTLP YTFNFYVLTN GSWSLTNKPS NTPFKPPAEM LSSITYFENF
     YKKSYQGRVL TFLYDFSRAD VDSRQVKGKI YKLSTTAYQM AILLMFNSAD KVTRFQINDT
     IGLDENTVRI PLLSLIKVGV IDCSDANYKS WNNDTEFNVN SKFTSKKMKV NCNISVQIGE
     NKTSEGQQTV SDQEVEKERF FKLQAAIVRI MKSKKTLSHN ELTVETTTQV SKWFTPKIAS
     IKKAIEYLID QEYIRRTNDD NPSARKYEYM A
//