ID   F0ZGN0_DICPU            Unreviewed;       955 AA.
AC   F0ZGN0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN   ORFNames=DICPUDRAFT_97430 {ECO:0000313|EMBL:EGC36914.1};
OS   Dictyostelium purpureum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC36914.1, ECO:0000313|Proteomes:UP000001064};
RN   [1] {ECO:0000313|Proteomes:UP000001064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX   PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA   Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA   Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA   Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA   Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA   Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA   Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT   "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT   Dictyostelium purpureum.";
RL   Genome Biol. 12:R20.1-R20.23(2011).
CC   -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC       transduction pathway. {ECO:0000256|ARBA:ARBA00037092}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GL871013; EGC36914.1; -; Genomic_DNA.
DR   RefSeq; XP_003286557.1; XM_003286509.1.
DR   AlphaFoldDB; F0ZGN0; -.
DR   STRING; 5786.F0ZGN0; -.
DR   EnsemblProtists; EGC36914; EGC36914; DICPUDRAFT_97430.
DR   GeneID; 10503972; -.
DR   KEGG; dpp:DICPUDRAFT_97430; -.
DR   eggNOG; KOG4407; Eukaryota.
DR   InParanoid; F0ZGN0; -.
DR   OMA; VSPIEPY; -.
DR   OrthoDB; 24457at2759; -.
DR   Proteomes; UP000001064; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23176:SF0; RHO GTPASE-ACTIVATING PROTEIN GACT; 1.
DR   PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001064}.
FT   DOMAIN          125..337
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          15..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          364..451
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          478..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          681..710
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          905..935
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          536..599
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          859..893
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        23..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..446
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        907..935
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   955 AA;  108536 MW;  D30C802311999F13 CRC64;
     MKSIFRKSVQ IFKDKKDKDG VYINNSGGNN DGNGSNNGKS SPSSSLSKKD KKNKHGNNIA
     NTDFNNEYNQ GYHNGSISSN HSGQSPTLTR EDSISSYNSD STTISAASSP PIFIHNPNAR
     KVFGVPLSQV PCRPGSNVPI IIERLVDHIE KTSLTTEGLF RIPGREVTIN QYINLYNNGE
     DVDVSPIEPY TAAGLLKRFF RDLPVFVPQS INRRVASLFV SEDGKKKPFD MEILGNLRIL
     VHQLPTVHFE VMQALTGLLA KIMSKSDENK MTISNIAICL VPTLNCVPAI VTYPIQYFNF
     FFNEIFQEHH IYHMRPYQTN LISTAIEERL EHLSHLSTQP MLIPNNNNSD VQKRYSRPAS
     ITISGLLPTQ NQSPSSSTIT STTITSPHDS TTPITFTVTT TFSPQDQQNG SPSQIHQHAQ
     QQLESGSGNQ QPTNTSTNAA TTTSNRDRRT YKIDPNEYAQ FLEETQYNIN KNYLHGGNTS
     NNLSQSSSNI SPSTTITNNN TNNNNNNNNN INNSYGSNSS ETNKLYRRSV AYTGGNIETK
     AAIQQIKEKI DRYSKEKKTR EDKEREKLLR YSIDLERYKD RYNKEKRSSR DINKEIEREI
     EKRLSPRERL NLLLASNNGT MNLSSSVNST LNRSSISGLS SLMNSANIND TSSNSGSNRR
     MSITQQLQMQ LQQLQQQQQA YQQQQQSTTP MGLNNNTTTT STTTNSNRYS SNRYKAVGDL
     ASSSSSFRYS REIYDDDYYS NNNMMFNNNF NDNMSSISGS SASAFSRQRS QSCFEPESLI
     QQLTLQQQQY QQQQQQQSYQ QPYQMNPQYS NAFIEQKLDQ IRDTINNLHR DNRVSRDYTH
     YLREVEDLRE TLQKETVTTE FFANKNQELE DKLRREEEKN KRLVEEIQLL ESYFVLKEKS
     KLSKRLSTRS RSPTLHGSFN HNNDPLNSSS NSIHSYVSNN VNLNQQQTLN NPNNN
//