ID F0ZVI6_DICPU Unreviewed; 552 AA.
AC F0ZVI6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=DICPUDRAFT_39002 {ECO:0000313|EMBL:EGC32049.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC32049.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC PRP16 sub-subfamily. {ECO:0000256|ARBA:ARBA00038040}.
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DR EMBL; GL871215; EGC32049.1; -; Genomic_DNA.
DR RefSeq; XP_003291435.1; XM_003291387.1.
DR AlphaFoldDB; F0ZVI6; -.
DR STRING; 5786.F0ZVI6; -.
DR EnsemblProtists; EGC32049; EGC32049; DICPUDRAFT_39002.
DR GeneID; 10507615; -.
DR KEGG; dpp:DICPUDRAFT_39002; -.
DR eggNOG; KOG0924; Eukaryota.
DR InParanoid; F0ZVI6; -.
DR OMA; QMGCTAE; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0034458; F:3'-5' RNA helicase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064}.
FT DOMAIN 41..217
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 519..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 470..497
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 519..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 62365 MW; 22A26C66C031D4EC CRC64;
MDSKKFSMFF GDVPVFTIPG RTFPVDVLWS KTPCEDYVDS AVKQILSIHV TQGEGDILVF
MTGQEDIETT CATVEERIKQ LGSSAPPLTL LPIYSQLPSD MQAKIFEKAD KGSRKCIIAT
NIAETSLTVD GILYVIDTGY CKLKVYNPRV GMDSLQVTPI SKANANQRSG RAGRTGPGRC
YRLYTESAYK HELMDNNIPE IQRTNLSNVV LNLKSMGIEN LLDFDFMDPP PQDNILNSMY
QLWVLGALDD SGKITELGQK MAEFPLDPPL SKMVIIGEKL GCADDIVTVV SMLSIPSVFY
RPKGAEEESD ASREKFFVPE SDHLTLLHIY QQWKINQFSS QWCAEHFIHV KAMRKVREIR
GQLLDIMKQH HMKIESCGSN WDLIRKAITS SYFHHSAKIK GIGEYVNMRN GMPCFLHPTS
ALYGLGYAPD YIVYHELVMT SKEYMQVVTA VDAQWLAEMG PMFFSIKKSL KDKKRKLDKI
EDKIEDINEK DKDKDENDNQ KEILENPIKK IGNKLLSTST SVVTSSNNSN STNKSKEKTT
SNNPRKTKRF GL
//
