ID F110B_HUMAN Reviewed; 370 AA.
AC Q8TC76; Q5BM08; Q9Y4K2;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 24-JAN-2024, entry version 147.
DE RecName: Full=Protein FAM110B;
GN Name=FAM110B; Synonyms=C8orf72;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Colon carcinoma;
RA Li X.-N., Li Y.-L., Liu G.-B., Ding Y.-Q.;
RT "Molecular cloning and bioinformatic analysis of a novel tumor-associated
RT gene MGC39325.";
RL Shi Jie Hua Ren Xiao Hua Za Zhi 13:1059-1064(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=17499476; DOI=10.1016/j.ygeno.2007.03.002;
RA Hauge H., Patzke S., Aasheim H.-C.;
RT "Characterization of the FAM110 gene family.";
RL Genomics 90:14-27(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=9110174; DOI=10.1101/gr.7.4.353;
RA Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W.,
RA Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.;
RT "Large-scale concatenation cDNA sequencing.";
RL Genome Res. 7:353-358(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [9]
RP VARIANT [LARGE SCALE ANALYSIS] SER-214.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in tumor progression.
CC -!- INTERACTION:
CC Q8TC76; O75031: HSF2BP; NbExp=3; IntAct=EBI-2558383, EBI-7116203;
CC Q8TC76; Q99687-3: MEIS3; NbExp=3; IntAct=EBI-2558383, EBI-18582591;
CC Q8TC76; P55347: PKNOX1; NbExp=3; IntAct=EBI-2558383, EBI-1373569;
CC Q8TC76; Q96KN3: PKNOX2; NbExp=5; IntAct=EBI-2558383, EBI-2692890;
CC Q8TC76; P62258: YWHAE; NbExp=2; IntAct=EBI-2558383, EBI-356498;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17499476}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000269|PubMed:17499476}.
CC -!- TISSUE SPECIFICITY: Detected in thyroid, spleen and testis, and at
CC lower levels in stomach, spinal cord, lymph node, trachea, adrenal
CC gland, prostate, ovary and intestine. {ECO:0000269|PubMed:17499476}.
CC -!- SIMILARITY: Belongs to the FAM110 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB50224.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY937246; AAX28928.1; -; mRNA.
DR EMBL; DQ431182; ABD92774.1; -; mRNA.
DR EMBL; U79298; AAB50224.1; ALT_INIT; mRNA.
DR EMBL; BC024294; AAH24294.1; -; mRNA.
DR CCDS; CCDS6170.1; -.
DR RefSeq; NP_671722.1; NM_147189.2.
DR RefSeq; XP_005251381.1; XM_005251324.2.
DR RefSeq; XP_005251382.1; XM_005251325.3.
DR RefSeq; XP_005251383.1; XM_005251326.2.
DR RefSeq; XP_016869437.1; XM_017013948.1.
DR AlphaFoldDB; Q8TC76; -.
DR BioGRID; 124703; 69.
DR IntAct; Q8TC76; 14.
DR MINT; Q8TC76; -.
DR STRING; 9606.ENSP00000355204; -.
DR iPTMnet; Q8TC76; -.
DR PhosphoSitePlus; Q8TC76; -.
DR BioMuta; FAM110B; -.
DR DMDM; 74730569; -.
DR MassIVE; Q8TC76; -.
DR PaxDb; 9606-ENSP00000355204; -.
DR PeptideAtlas; Q8TC76; -.
DR ProteomicsDB; 74097; -.
DR Pumba; Q8TC76; -.
DR Antibodypedia; 2031; 113 antibodies from 13 providers.
DR DNASU; 90362; -.
DR Ensembl; ENST00000361488.7; ENSP00000355204.3; ENSG00000169122.12.
DR Ensembl; ENST00000519262.6; ENSP00000509301.1; ENSG00000169122.12.
DR GeneID; 90362; -.
DR KEGG; hsa:90362; -.
DR MANE-Select; ENST00000519262.6; ENSP00000509301.1; NM_001377989.1; NP_001364918.1.
DR UCSC; uc003xtj.2; human.
DR AGR; HGNC:28587; -.
DR CTD; 90362; -.
DR DisGeNET; 90362; -.
DR GeneCards; FAM110B; -.
DR HGNC; HGNC:28587; FAM110B.
DR HPA; ENSG00000169122; Low tissue specificity.
DR MIM; 611394; gene.
DR neXtProt; NX_Q8TC76; -.
DR OpenTargets; ENSG00000169122; -.
DR PharmGKB; PA162385659; -.
DR VEuPathDB; HostDB:ENSG00000169122; -.
DR eggNOG; ENOG502R37V; Eukaryota.
DR GeneTree; ENSGT00950000183056; -.
DR HOGENOM; CLU_050540_0_0_1; -.
DR InParanoid; Q8TC76; -.
DR OMA; IASMKSP; -.
DR OrthoDB; 5407076at2759; -.
DR PhylomeDB; Q8TC76; -.
DR TreeFam; TF330964; -.
DR PathwayCommons; Q8TC76; -.
DR SignaLink; Q8TC76; -.
DR BioGRID-ORCS; 90362; 18 hits in 1154 CRISPR screens.
DR ChiTaRS; FAM110B; human.
DR GenomeRNAi; 90362; -.
DR Pharos; Q8TC76; Tbio.
DR PRO; PR:Q8TC76; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8TC76; Protein.
DR Bgee; ENSG00000169122; Expressed in cortical plate and 166 other cell types or tissues.
DR ExpressionAtlas; Q8TC76; baseline and differential.
DR Genevisible; Q8TC76; HS.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR InterPro; IPR025740; FAM110.
DR InterPro; IPR025741; FAM110_C.
DR InterPro; IPR025739; FAM110_N.
DR PANTHER; PTHR14758; AGAP005440-PA; 1.
DR PANTHER; PTHR14758:SF2; PROTEIN FAM110B; 1.
DR Pfam; PF14160; FAM110_C; 1.
DR Pfam; PF14161; FAM110_N; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..370
FT /note="Protein FAM110B"
FT /id="PRO_0000285651"
FT REGION 127..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 238
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C739"
FT MOD_RES 301
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"
FT VARIANT 214
FT /note="A -> S (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs150740446)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036319"
FT CONFLICT 41
FT /note="A -> T (in Ref. 1; AAX28928)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="F -> Y (in Ref. 1; AAX28928)"
FT /evidence="ECO:0000305"
FT CONFLICT 345
FT /note="I -> N (in Ref. 1; AAX28928)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 370 AA; 40728 MW; 7D0F066083AE6C1B CRC64;
MPTETLQTGS MVKPVSPAGT FTSAVPLRIL NKGPDYFRRQ AEPNPKRLSA VERLEADKAK
YVKSQEVINA KQEPVKPAVL AKPPVCPAAK RALGSPTLKV FGNHAKTESG VQRENLKLEI
LKNIINSSEG SSSGSGHKHS SRNWPPHRSE ATDLHRHSFA ESLKVYPTQG RRSPQEGGSH
VGRRLLEQSA ESFLHVSHSS SDIRKVTSVK PLKAIPCSSS APPLPPKPKI AAIASMKSPE
ADPVEPACGV SRRPSLQRSK SDLSDRYFRV DADVERFFNY CGLDPEELEN LGMENFARAN
SDIISLNFRS ASMISSDCEQ SQDSNSDLRN DDSANDRVPY GISAIERNAR IIKWLYSIKQ
ARESQKVSHV
//
