ID F1BYD8_9HIV1 Unreviewed; 848 AA.
AC F1BYD8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ADY17368.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ADY17368.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADY17368.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=0201C15 {ECO:0000313|EMBL:ADY17368.1};
RX PubMed=15858036; DOI=10.1128/JVI.79.10.6523-6527.2005;
RA Frost S.D., Liu Y., Pond S.L., Chappey C., Wrin T., Petropoulos C.J.,
RA Little S.J., Richman D.D.;
RT "Characterization of human immunodeficiency virus type 1 (HIV-1) envelope
RT variation and neutralizing antibody responses during transmission of HIV-1
RT subtype B.";
RL J. Virol. 79:6523-6527(2005).
RN [2] {ECO:0000313|EMBL:ADY17368.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=0201C15 {ECO:0000313|EMBL:ADY17368.1};
RA Choi J.Y.;
RT "Correlates in the V1-V4 coding region of HIV-1 envelope during
RT transmission after sexual exposure.";
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; HQ162599; ADY17368.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR HAMAP; MF_04083; HIV_ENV; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR037527; Gp160.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Clathrin-mediated endocytosis of virus by host
KW {ECO:0000256|ARBA:ARBA00022570};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host endosomal membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ADY17368.1};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022570};
KW Virion {ECO:0000313|EMBL:ADY17368.1};
KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00022570}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 670..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..503
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 522..711
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 710..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..736
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 848
FT /evidence="ECO:0000313|EMBL:ADY17368.1"
SQ SEQUENCE 848 AA; 96189 MW; C690EC0058A295FB CRC64;
MRVRGIRKNY QRLWRWGIML LGMLMICSAV ENLWVTVYYG VPVWKEATTT LFCASDAKAY
DTEVHNVWAT HACVPTDPSP QEVILENVTE NFNMWKNDMV EQMQEDIISL WDQSLKPCAK
LTPLCVTLNC TDTNTTTTNS SSWERVETGE IKNCSFNVTT NIGDKRQKEY ALFYKLDVVK
IGNSSNYRLM SCNTSVITQA CPKISFEPIP IHYCAPAGFA ILKCKDKKFN GTGPCSNVST
VQCTHGIRPV VSTQLLLNGS LAEEDVMIRS QNFTNNAKVI IVQLTEAIKI NCTRPNNNTR
KSIHIGPGRA FYATGDIIGN IRQAHCNISS ANWNNTLKQI VKKLREQFKN KTIAFKQSSG
GDPEIVMHSF NCGGEFFYCN TTQLFNSTWN STTWNENNTD NNDKNITLQC KIKQVINMWQ
TVGKAMYAPP IPGQIRCSSN ITGLLLTRDG GNESSETETF RPGGGDMRDN WRSELYKYKV
VKIEPLGVAP TKAKRRVVQR EKRAVGIGAV FLGFLGAAGS TMGAASLTLT VQARLLLSGI
VQQQNNLLRA IEAQQHMLQL TVWGIKQLQA RVLAVERYLK DQQLLGIWGC SGKLICTTAV
PWNTSWSNKS LNNIWDNMTW MEWDREINNY SSIIYSLLEE SQNQQEKNEQ ELLELDKWAN
LWSWFDISNW LWYIKIFIMI VGGLVGLRIV FSVLSIVNRV RQGYSPLSFQ TRLPNPGEPD
RPEGIEGEGG ERNRDRSRRS ADGFLTIIWI DLRSLCLFSY HRLRDLLLIV TRIVELLGRR
GWEAIKYWWN LLQYWSQELA NSAVSLLNTI AIAVAEGTDR LLEGLQRAGR AILHIPTRIR
QGLERALV
//
