ID F1CDV5_9HIV1 Unreviewed; 837 AA.
AC F1CDV5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ADZ13414.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ADZ13414.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADZ13414.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=19642pb38_2_7 {ECO:0000313|EMBL:ADZ13414.1};
RX PubMed=20638697; DOI=10.1016/j.virol.2010.06.029;
RA Edo-Matas D., van Gils M.J., Bowles E.J., Navis M., Rachinger A.,
RA Boeser-Nunnink B., Stewart-Jones G.B., Kootstra N.A., van 't Wout A.B.,
RA Schuitemaker H.;
RT "Genetic composition of replication competent clonal HIV-1 variants
RT isolated from peripheral blood mononuclear cells (PBMC), HIV-1 proviral DNA
RT from PBMC and HIV-1 RNA in serum in the course of HIV-1 infection.";
RL Virology 405:492-504(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; HQ231130; ADZ13414.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR HAMAP; MF_04083; HIV_ENV; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR037527; Gp160.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Clathrin-mediated endocytosis of virus by host
KW {ECO:0000256|ARBA:ARBA00022570};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host endosomal membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ADZ13414.1};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022570};
KW Virion {ECO:0000313|EMBL:ADZ13414.1};
KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00022570}.
FT TRANSMEM 659..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..491
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 511..700
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 700..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADZ13414.1"
SQ SEQUENCE 837 AA; 94706 MW; C5EB416BDF9947D5 CRC64;
CSAAERLWVT VYYGVPVWKE ANTTLFCASD AKAYSTEVHN VWATHACVPT DPNPQEVELK
NVTENFNMWK NSMVEQMHED IISLWDQSLK PCVKLTPLCV TLNCTDYWGN TTNLGNTTNE
KNDTGTNKAT NTTEIKKCSF NITTILRDKV RKEYALFYKS DVVPIKNDST SYRLISCNTS
TITQACPKVT FEPIPIHYCA PAGFAILKCK DKKFNGTGPC KNVSTVRCTH GIRPVVSTQL
LLNGSLAEEE AVIRSANFSD NAKTIIVQLN ESVIINCTRP NNNTRKSIPI GPGRAFYATG
DIIGDIRQAH CNISGIQWNN TLRQIAKKLK EQFKNTTTIA FKQSSGGDPE IIMHTFNCGG
EFFYCNTSKL FNSTWNDTTL NDMDDIKNNT NITLPCRIKQ IINMWQEVGK AMYAPPIQGQ
IRCTSNITGL LITRDGGTNN DTQGTETFRP GGGDMRDNWR SELYKYKVVR IEPLGVAPTK
AKRRVVQREK RAIGGLGALF LGFLGTAGST MGAASITLTV QARQLLSGIV QQQNNLLRAI
EAQQHLLQLT VWGIKQLQAR VLAVERYLKD QQLLGMWGCS GKLICTTAVP WNTSWSNKSM
NQIWDNMTWM QWEKEIDNYT SLIYSLIEDS QIQQEKNEQE LLELDKWGSL WTWFNITNWL
WYIRIFIMIV GGLIGLRIVF AVISIVNRVR QGYSPLSFQT HLPAPRGPDR PEGIEEEGGE
RDRGRSGPLV DGFLALIWID LRSLCLFSYH RLRDLLLIVT RIVELLGRRG WEALKYWWNL
LQYWSQELKN SAVSLFNAVA IAVAEGTDRV LEVLQRIFRA ILHIPTRIRQ GLERALL
//
