ID F1KEV3_9HIV1 Unreviewed; 238 AA.
AC F1KEV3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ADY90768.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ADY90768.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ADY90768.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADY90768.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=09clone61 {ECO:0000313|EMBL:ADY90768.1};
RX PubMed=21241214; DOI=10.1089/aid.2010.0346;
RA Persaud D., Bedri A., Ziemniak C., Moorthy A., Gudetta B., Abashawl A.,
RA Mengistu Y., Omer S.B., Isehak A., Kumbi S., Adamu R., Lulseged S.,
RA Ashworth R., Hassen E., Ruff And The Ethiopian Swen Study Team A.;
RT "Slower Clearance of Nevirapine Resistant Virus in Infants Failing Extended
RT Nevirapine Prophylaxis for Prevention of Mother-to-Child HIV
RT Transmission.";
RL AIDS Res. Hum. Retroviruses 27:823-829(2011).
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DR EMBL; JF334339; ADY90768.1; -; Genomic_DNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 39..229
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADY90768.1"
FT NON_TER 238
FT /evidence="ECO:0000313|EMBL:ADY90768.1"
SQ SEQUENCE 238 AA; 27599 MW; CFB2C7EA218B277B CRC64;
ETVPVKLKPG VDGPKVKQWP LTEEKIKALT AICDEMEKEG KISRIGPENP YNTPVFAIKK
KDSTKWRKLV DFRELNKRTQ DFWEVQLGIP HPAGLKQKKS VTVLDVGDAY FSVPLDESFR
KYTAFTIPSI NNETPGIRYQ YNVLPQGWKG SPSIFQSSMT KILEPFRTKN PEIVICQYMD
DLYVGSDLEI GQHRAKIEEL REHLLRWGFT TPDKKHQKEP PFLWMGYELH PDKWTVQP
//
