ID F1KFK3_9HIV1 Unreviewed; 239 AA.
AC F1KFK3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ADY91018.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ADY91018.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ADY91018.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADY91018.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=12persistclone78 {ECO:0000313|EMBL:ADY91018.1};
RX PubMed=21241214; DOI=10.1089/aid.2010.0346;
RA Persaud D., Bedri A., Ziemniak C., Moorthy A., Gudetta B., Abashawl A.,
RA Mengistu Y., Omer S.B., Isehak A., Kumbi S., Adamu R., Lulseged S.,
RA Ashworth R., Hassen E., Ruff And The Ethiopian Swen Study Team A.;
RT "Slower Clearance of Nevirapine Resistant Virus in Infants Failing Extended
RT Nevirapine Prophylaxis for Prevention of Mother-to-Child HIV
RT Transmission.";
RL AIDS Res. Hum. Retroviruses 27:823-829(2011).
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DR EMBL; JF334669; ADY91018.1; -; Genomic_DNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 40..230
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADY91018.1"
FT NON_TER 239
FT /evidence="ECO:0000313|EMBL:ADY91018.1"
SQ SEQUENCE 239 AA; 27723 MW; 096AA4DD12F17D6A CRC64;
PETVPVKLKP GMDGPKVKQW PLTEEKIKAL TAICEEMEKE GKISKIGPDN PYNTPVFAIK
KKDSTKWRKL VDFRELNKRT QDFWEVQLGI PHPAGLKKKK SVTVLDVGDA YFSVPLDESF
RKYTAFTIPS INNETPGIRY QYNVLPQGWK GSPSIFQSSM TRILEPFRAN NPEIVICQYM
DDLYVGSDLE IGQHREKVEQ LREHLLKWGF TTPDKKHQKE PPFHWMGYEL HPDKWTVQP
//
