ID F1KW43_ASCSU Unreviewed; 529 AA.
AC F1KW43;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY42097.1};
RN [1] {ECO:0000313|EMBL:ADY42097.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21685128; DOI=10.1101/gr.121426.111;
RA Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA Davis R.E.;
RT "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT functional diversification, and novel developmental profiles.";
RL Genome Res. 21:1462-1477(2011).
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; JI166859; ADY42097.1; -; mRNA.
DR AlphaFoldDB; F1KW43; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF106; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 4.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51214; IBB; 1.
PE 2: Evidence at transcript level;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 5..67
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REGION 28..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 59020 MW; F6EA45F9C35487A0 CRC64;
MSLTNKTNTM SCKAEEIKEE RMKQYKNIGK HEELRRRRAE CSVELRKQKR ENEMMKRRNV
DLSEQFESED SSNEQKLESL SKDGTPKLTV SEAVVILQNN PSVEQMRCCF EAIRRLLSRS
KTPPIDEVIK SGLVTALVQA LSVSDEKVQF EAAWGITNIV SGTTEQTVAV VNEGALPPLV
QLCYSKNKAL AEQALWAMAN VIGDSAQLRD QAVECGVLEA LDYVVGKVEE LSEEFARTIA
WTYSNICRHK KPSLSIAVLR RLAPAIVKLL SHKDNPVRQD ACWALSYLTD GSDEQIKVAG
DANCMPALMP LVQSGNDAEV APAIRVFGNF ATGSDDLTQM VVDAGVLECI DHVIRSAKSL
SIEKECCWLL SNVIAGTHAQ IQAVLDARLL PTIFTALRDG DFRSKFEASW AVSNLAHGGS
SAQVMELSND EYITVLCNLL DVPNADFICN LLDTLFIVLK TAQNLYPDRL KQIEDSVESS
GGLDRLEMLQ ENENTRVYEW SYKIIEQFFT DEADEQIDDE IPDDQPINF
//
