ID F1KZ87_ASCSU Unreviewed; 354 AA.
AC F1KZ87;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Leucine aminopeptidase 1 {ECO:0000313|EMBL:ADY43191.1};
OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY43191.1};
RN [1] {ECO:0000313|EMBL:ADY43191.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21685128; DOI=10.1101/gr.121426.111;
RA Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA Davis R.E.;
RT "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT functional diversification, and novel developmental profiles.";
RL Genome Res. 21:1462-1477(2011).
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
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DR EMBL; JI168430; ADY43191.1; -; mRNA.
DR AlphaFoldDB; F1KZ87; -.
DR MEROPS; M17.A05; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR Gene3D; 3.40.50.10590; Zn-dependent exopeptidases; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR041417; NPEPL1_N.
DR InterPro; IPR000819; Peptidase_M17_C.
DR PANTHER; PTHR11963:SF4; AMINOPEPTIDASE NPEPL1-RELATED; 1.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR Pfam; PF18295; Pdase_M17_N2; 1.
DR Pfam; PF00883; Peptidase_M17; 1.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 2: Evidence at transcript level;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW ECO:0000313|EMBL:ADY43191.1}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 35..154
FT /note="Probable aminopeptidase NPEPL1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18295"
FT DOMAIN 194..336
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF00883"
SQ SEQUENCE 354 AA; 37927 MW; 8E1ABAD11ED3A6A4 CRC64;
MRGLLRTFAA SIKKMSSFAV RAGLSVTDVL SAERQVLLVG KQKQLKVLNF ENGLKSKLAD
CVSPKLWQQA LSSLSAKSSC SVPLHLNLAK VISVPDEVSR HNAPSNAIAI FKEVKATSRP
EGVKNVSVVL YSDITDVFAS VAAISRCFPL YDRHTKVNCP LEKVDVEVVV PGPQKLSDAD
VNFLQTLCDS VRTAARMIDT PCNELHTEAF ADEAITFVGK LSGVTSTIIK GQDLLKQGFG
GIYHVGKAAA HPPIFACFSY KPSGATQTYA LVGKGIVYDS GGMSIKSKTI MPGMKEDMGG
AAGMLSSFYT LVKSGFNQNL HCLLCIAENS VSPEANLSKS DSLQRFDVAA VQTM
//
