ID F1L189_ASCSU Unreviewed; 594 AA.
AC F1L189;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=TWiK family of potassium channels protein 18 {ECO:0000313|EMBL:ADY43893.1};
OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY43893.1};
RN [1] {ECO:0000313|EMBL:ADY43893.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21685128; DOI=10.1101/gr.121426.111;
RA Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA Davis R.E.;
RT "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT functional diversification, and novel developmental profiles.";
RL Genome Res. 21:1462-1477(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; JI169449; ADY43893.1; -; mRNA.
DR AlphaFoldDB; F1L189; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF307; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:ADY43893.1};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 221..271
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 374..446
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..571
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 69068 MW; D2EE21D4B9211379 CRC64;
MDSNRTRTPN GDYMRKASMS RARSAEPLRK ESTLPVNLIN IAKRSGNVSS SVAGDLATPA
TNGSRPFNVS EEVEKPHRRR RRRKRIEVIE DKPKYTPPPQ PPRKETKGGR TIWRNIVWLI
ILFAYSLAGG IAFSAIEGGN DRTDCLRKYE RELDIYEGRI KFQDQLFARF REVEYDTSFN
GNRTDDNDGV DVKLHLMREA IAEYERRLGF EVKEPIMTDT KWNLWGGVYY SASLYTTIGY
GNFFPKTQAG QIFSMVYAFC GIPLVFTILL EWGFLYFTWI EIFWKWFNQK LCFNSMEAHL
KKRIAKERLR RAGSELSLRS TSVTPLMKNA VQQKDAIHQT DHQIESGKRI AQLEIELSEA
EKQRTVPLKA ALIFFFLWIL ISAFIVRLWE RNWTYFTAYY YFFTSLTTIG LGDVVTETPN
FIIFNLALTM VGLSVVGLCI AIVQAKIRLI FDRMIRSIDS QYRIRQIDPD VATMTLITDE
KEGIKRLCEA QPIQDRIIFI AMDEHKKQLL ADRWKQKSSM INRITQTWPN RADKCIQTGQ
RVDEQPRMRP EGDYGDEWEE VSTGSDESTE NEYDEDGKRI VPPSTRRYIY TVFD
//
