ID F1L352_ASCSU Unreviewed; 479 AA.
AC F1L352;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Notchless protein 1 {ECO:0000313|EMBL:ADY44556.1};
OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY44556.1};
RN [1] {ECO:0000313|EMBL:ADY44556.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21685128; DOI=10.1101/gr.121426.111;
RA Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA Davis R.E.;
RT "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT functional diversification, and novel developmental profiles.";
RL Genome Res. 21:1462-1477(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR EMBL; JI170447; ADY44556.1; -; mRNA.
DR AlphaFoldDB; F1L352; -.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001632; Gprotein_B.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19848:SF0; NOTCHLESS PROTEIN HOMOLOG 1; 1.
DR PANTHER; PTHR19848; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00319; GPROTEINB.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 7.
PE 2: Evidence at transcript level;
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 14..74
FT /note="NLE"
FT /evidence="ECO:0000259|Pfam:PF08154"
FT REPEAT 108..149
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 150..191
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 193..239
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 240..280
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 362..393
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 404..438
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 446..479
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 479 AA; 53245 MW; BB3B6AF0B325E396 CRC64;
MEIDEEDNEH RIGIRLFSEE GTELSDAPIV VALSTNAQQL QVLCNKLLGN SDDPIPISFQ
LKNGIEIRES IADSVPQDKL NVEKNIELVY YPEAVFRVRP VTRCTSSLPG HGEPVISIQF
SPDGRGLASG SGDCTVRFWD VDTELPLRTC KAHTSWVLCI AWSPDAKKLA SACKNGHICL
WNAHTGAQIG KKLTGHKQWI NQLAWQPFHQ DPISRFLASA GKDGMIRIWD TVNYTVVRAL
SGHTASVTSI RWGGEGLIYS GSQDRMVKVW RAEDGVLCRT LSGHAHWVNT LALNVEYALR
TSCFDPKNQC IAPDQIEECR KIAQLRYEKA KGASGEILVS GSDDFTLYLW RPTTEKKPVA
RMTGHQQLIN QVVFSPDARY IASASFDKSI KLWCGRTGAF IDTLRGHVQA VYQIAWSADS
RLLVSGSADS TLKVWDMRKR GICEDLPGHG DEVYAVDWSP DGERVASGGK DKVLKLWRL
//
