ID F1L8X8_ASCSU Unreviewed; 334 AA.
AC F1L8X8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 08-NOV-2023, entry version 23.
DE RecName: Full=Snurportin-1 {ECO:0000256|ARBA:ARBA00016034};
OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY46582.1};
RN [1] {ECO:0000313|EMBL:ADY46582.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21685128; DOI=10.1101/gr.121426.111;
RA Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA Davis R.E.;
RT "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT functional diversification, and novel developmental profiles.";
RL Genome Res. 21:1462-1477(2011).
CC -!- FUNCTION: Functions as an U snRNP-specific nuclear import adapter.
CC Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import
CC of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
CC {ECO:0000256|ARBA:ARBA00003975}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the snurportin family.
CC {ECO:0000256|ARBA:ARBA00007540}.
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DR EMBL; JI174133; ADY46582.1; -; mRNA.
DR AlphaFoldDB; F1L8X8; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0061015; P:snRNA import into nucleus; IEA:InterPro.
DR CDD; cd09232; Snurportin-1_C; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR InterPro; IPR017336; Snurportin-1.
DR InterPro; IPR024721; Snurportin-1_N.
DR InterPro; IPR047857; Snurportin1_C.
DR PANTHER; PTHR13403:SF6; SNURPORTIN-1; 1.
DR PANTHER; PTHR13403; SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1; 1.
DR Pfam; PF11538; Snurportin1; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 23..63
FT /note="Snurportin-1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11538"
FT REGION 290..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 334 AA; 38070 MW; A00F860E52C90420 CRC64;
MDELVTMLAG SSVTHPASTT GEHPHFSLYK NARKIEANQK RRREEYLARQ KEARFNYASR
ARNLAMNTFD NEEEEMDVDT KVTSKGKRRR NRYADELMLS EWLVDIPETL SSDWICVPCP
VGKRALVVAS NGVTNAYSKS GYLLKQFSSY LPGGNRSSCS HYTLLDCVFS SEQSTFYCLD
MIAWNDTIVA DSDFDCRLFL LNSRITENEN FKEVSKQFPY RFLCLPTCRC DKSLMEQLML
TEFTFELDGV LFYHTAALYR PGRSPLVGWL KPWMMPEILS VKIPASLMKG NSTTKGTSQK
FINDYNSGHK RQPKRDGSES AVMECLSADA NVES
//
