ID F1LB94_ASCSU Unreviewed; 367 AA.
AC F1LB94;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Dauer larva development regulatory growth factor daf-7 {ECO:0000313|EMBL:ADY47398.1};
DE Flags: Fragment;
OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY47398.1};
RN [1] {ECO:0000313|EMBL:ADY47398.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21685128; DOI=10.1101/gr.121426.111;
RA Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA Davis R.E.;
RT "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT functional diversification, and novel developmental profiles.";
RL Genome Res. 21:1462-1477(2011).
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; JI176208; ADY47398.1; -; mRNA.
DR AlphaFoldDB; F1LB94; -.
DR EnsemblMetazoa; AgB03_g481_t01; AgB03_g481_t01; AgB03_g481.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19378; TGF_beta_DAF7; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF291; LD29161P; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..367
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003265512"
FT DOMAIN 256..367
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT NON_TER 367
FT /evidence="ECO:0000313|EMBL:ADY47398.1"
SQ SEQUENCE 367 AA; 42526 MW; 8CBEF29CCAA16E63 CRC64;
MYLGWWLAVL VCGLLHRSWL TEAWRNNHTC HSCAEARDQF AKIRLEQIKR EILEKLGLDG
PPQVRPSEGF PSIPQVAKYL RSQVRRDIHS SFLADEPAYG TVEQKTEQTI IIAERAPVRY
NQNWLVGHFR FSNEIMSKSL RRAFLYVFLR KPSNFHFESR ISTVQVIVRE VLKDGKYGAD
VAERKRHIDL GREAYVQIPL RIDDLQRWWD GEGPKNEFLG LYVEALYRGE NLAVHPQQDP
INLMYMELTS IDEWTRRKRS STEMCTREMN EPSCCLYSLV VDFEAAGWDF VIAPKLYDAH
MCSGECRLHH PDRSPHSKIT SSTSKNTVSG CCHPSEYDPI TLVYMTEEKE VKIKEVPGMI
ARRCACA
//
