ID   F1LKT9_METAN            Unreviewed;       390 AA.
AC   F1LKT9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Subtilisin-like protease Pr1A {ECO:0000313|EMBL:ACV71835.1};
GN   Name=pr1A {ECO:0000313|EMBL:ACV71835.1};
OS   Metarhizium anisopliae (Entomophthora anisopliae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=5530 {ECO:0000313|EMBL:ACV71835.1};
RN   [1] {ECO:0000313|EMBL:ACV71835.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CG341 {ECO:0000313|EMBL:ACV71835.1};
RA   Bandinelli J.B., Silva F.B., Pereira T.C.B., Fagundes N.J.R.,
RA   Dallonder L.P., Yanaka F.Y., Bogo M.R.;
RT   "Genetic diversity and evolutive relationships of the entomopathogen
RT   Metarhizium anisopliae strains inferred from the subtilisin-like Pr1A.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR   EMBL; FJ659162; ACV71835.1; -; Genomic_DNA.
DR   AlphaFoldDB; F1LKT9; -.
DR   MEROPS; S08.056; -.
DR   VEuPathDB; FungiDB:MAN_03501; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR   Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   PANTHER; PTHR43806:SF69; PROTEINASE T; 1.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..390
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012722998"
FT   DOMAIN          42..106
FT                   /note="Inhibitor I9"
FT                   /evidence="ECO:0000259|Pfam:PF05922"
FT   DOMAIN          139..375
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   REGION          274..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        148
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        179
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        334
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   390 AA;  40420 MW;  8E5EE6FEA69F46E5 CRC64;
     MHLSALLTLL PAVLAAPATI GRRAEPAPLF TPQAESIIAD KYIVKFKDDI ARIATDDTVS
     ALTSKADFVY EHAFHGFAGS LTKEELKMLR EHPGVDFIEK DAVMRISGLT EQSGAPWGLG
     RISHRNRGST TYRYDDSAGE GTCVYIIDTG IEASHPEFEG RATFLRSFIS GQETDGHGHG
     THCAGTIGSK SYGVAKKAKL YGVKVLDNQG SGSYSGIISG MDYVASDSKT RGCPKGAIAS
     MSLGGGYSAS VNQGAAALVN SGVFLAVAAG NDNRDAQNTS PASEPSACTV GATDSSDRRS
     SFSNFGRVVD IFAPGTGVLS TWIGGSTNTI SGTSMATPHI GGLAAYLSAL QGKTTPAALC
     KKIQDTATKN ALTGVPSGTV NYLAYNGNGA
//