ID F1LT30_RAT Unreviewed; 770 AA.
AC F1LT30;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=RNA binding motif protein 25 {ECO:0000313|Ensembl:ENSRNOP00000003834.7};
GN Name=Rbm25 {ECO:0000313|RGD:1308755};
GN Synonyms=AABR07065078.1 {ECO:0000313|Ensembl:ENSRNOP00000003834.7},
GN Rbm25l1 {ECO:0000313|RGD:1565486};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000003834.7, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000003834.7, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003834.7,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000003834.7}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003834.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1LT30; -.
DR IntAct; F1LT30; 1.
DR STRING; 10116.ENSRNOP00000003834; -.
DR jPOST; F1LT30; -.
DR PaxDb; 10116-ENSRNOP00000003834; -.
DR PeptideAtlas; F1LT30; -.
DR Ensembl; ENSRNOT00000003834.8; ENSRNOP00000003834.7; ENSRNOG00000002874.8.
DR AGR; RGD:1308755; -.
DR AGR; RGD:15003247; -.
DR RGD; 15003247; AABR07065078.1.
DR RGD; 1308755; Rbm25.
DR RGD; 1565486; Rbm25l1.
DR VEuPathDB; HostDB:ENSRNOG00000002874; -.
DR eggNOG; KOG2253; Eukaryota.
DR GeneTree; ENSGT00730000111019; -.
DR HOGENOM; CLU_882680_0_0_1; -.
DR InParanoid; F1LT30; -.
DR TreeFam; TF320185; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000002874; Expressed in spleen and 20 other cell types or tissues.
DR GO; GO:0016607; C:nuclear speck; ISO:RGD.
DR GO; GO:0003729; F:mRNA binding; ISO:RGD.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISO:RGD.
DR GO; GO:0042981; P:regulation of apoptotic process; ISO:RGD.
DR CDD; cd12446; RRM_RBM25; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR002483; PWI_dom.
DR InterPro; IPR036483; PWI_dom_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034268; RBM25_RRM.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR18806; RBM25 PROTEIN; 1.
DR PANTHER; PTHR18806:SF4; RNA-BINDING PROTEIN 25; 1.
DR Pfam; PF01480; PWI; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00311; PWI; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF101233; PWI domain; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS51025; PWI; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 45..122
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 677..770
FT /note="PWI"
FT /evidence="ECO:0000259|PROSITE:PS51025"
FT REGION 131..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..533
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 91769 MW; 78EF93EC8FB842DE CRC64;
WAYLVCNEFI VLVPTVSMVG KHLGARKDHP GLKLKENDEN CGPTTTVFVG NISEKASDML
IRQLLAKCGL VLSWKRVQGA SGKLQAFGFC EYKEPESTLR ALRLLHDLQI GEKKLLVKVD
AKTKAQLDEW KAKKKANGNA RPETVTNDDE EALDEETKRR DQMIKGAIEV LIREYSSELN
APSQESDSHP RKKKKEKKED IFRRFPVAPL IPYPLITKED INAIEMEEDK RDLISREISK
FRDTHKKLEE EKGKKEKERQ EIEKERRERE RERERERERR ERERERERER EREKEKERER
ERERDRDRDR TKERDRDRER DRDRDRERSS DRNKDRSRSR ERERERERER EREKDKKRDR
EEDEEDAYER RKLERKLREK EAAYQERLKN WEIRERKKTR EYEKEAEREE ERRREMAKEA
KRLKEFLEDY DDDRDDPKYY RGSALQKRLR DREKEMEADE RDRKREKEEL EEIRQRLLAE
GHPDPDAELQ RMEQEAERRR QPQIKQEPES EEEEEEKQEK EEKREEPVEE EEEPEQKPCL
KPTLRPISSA PSVSSASGNA TPNTPGDESP CGIIIPHENS PDQQQPEEHR PKIGLSLKLG
ASNSPGQPNS VKRKKLPVDS VFNKFEDEDS DDVPRKRKLV PLDYGEDDKN AAKGTVNTEE
KRKHIKSLIE KIPTAKPELF AYPLDWSIVD SILMERRIRP WINKKIIEYI GEEEATLVDF
VCSKVMAHSS PQSILDDVAM VLDEEAEVFI VKMWRLLIYE TEAKKIGLVK
//
