ID F1MJQ2_BOVIN Unreviewed; 1388 AA.
AC F1MJQ2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Contactin associated protein 1 {ECO:0000313|Ensembl:ENSBTAP00000025424.6};
GN Name=CNTNAP1 {ECO:0000313|Ensembl:ENSBTAP00000025424.6,
GN ECO:0000313|VGNC:VGNC:27540};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000025424.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000025424.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025424.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000025424.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025424.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, paranodal septate junction
CC {ECO:0000256|ARBA:ARBA00004403}.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR SMR; F1MJQ2; -.
DR STRING; 9913.ENSBTAP00000025424; -.
DR PaxDb; 9913-ENSBTAP00000025424; -.
DR Ensembl; ENSBTAT00000025424.6; ENSBTAP00000025424.6; ENSBTAG00000019097.6.
DR VEuPathDB; HostDB:ENSBTAG00000019097; -.
DR VGNC; VGNC:27540; CNTNAP1.
DR eggNOG; KOG3516; Eukaryota.
DR GeneTree; ENSGT00940000160825; -.
DR HOGENOM; CLU_003504_1_0_1; -.
DR InParanoid; F1MJQ2; -.
DR OMA; RSGCHSN; -.
DR TreeFam; TF321823; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000019097; Expressed in prefrontal cortex and 100 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033010; C:paranodal junction; IEA:UniProtKB-SubCell.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF43; CONTACTIN-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00122}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT DOMAIN 25..168
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 174..355
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 361..538
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 540..577
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 576..628
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT DOMAIN 785..957
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 958..996
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1049..1250
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1317..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1334..1374
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 930..957
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 1388 AA; 156428 MW; D943DAC53E16071E CRC64;
MMRLRLFCIL LAAVSGARGW GYYGCDEELV GPLYARSLGA SSYYGLFTAP RFARLHGISG
WSPRIGDPNP WLQIDLMKKH RIRAVATQGS FNSWDWVTRY MLLYGDRVDS WTPFYQRGHN
ATFFGNVNES AVVRHDLHYH FTARYIRIVP LAWNPRGKIG LRLGLYGCPY KSDVLYFDGD
DAISYRFPRG VSRSLWDVFA FSFKTEEKDG LLLHAEGAQG DYVTLELQGA HLLLHMSLGS
SPIQPRPGHT TVSAGGVLND QHWHYVRVDR FGREANLTLD GYVQRFVLNG DFERLNLDNE
MFIGGLVGAA QKNLAYRHNF RGCIENVIFN RVNIADLAVR RHSRITFEGK VAFRCLDPVP
HPINFGGPHN FVQVPGFPRR GRLAVSFRFR TWDLTGLLLF SSLGDGLGHV ELMLSEGQVN
VSVVQTGRKK LQFAAGFRLN DGFWHEVNFV AQENHAVISI DDVEGAEVRV SYPLLIRTGT
SYFFGGCPKP ASRSGCHSNQ TAFHGCMELL KVDGQLVNLT LVEGRRLGYY AEVLFDTCGI
TDRCSPNMCE HDGRCYQSWD DFICYCELTG YKGETCHQPL YKESCEAYRL SGKTSGNFTI
DPDGSGPLKP FVVYCDIREN RAWTVVRHDR LWTTRVTGSS MERPFLGAVQ YWNASWEEVS
ALANASQHCE QWIEFSCYNS RLLNTAGGYP YSFWIGRNEE QHFYWGGSQP GIQRCACGLD
RSCVDPALHC NCDADQPQWR TDKGLLTFVD HLPVTQVVVG DTNRSSSEAQ FFLRPLRCYG
DRNSWNTISF HTGAALRFPP IRANHSLDVS FYFRTSAPSG VFLENMGGPY CQWRRPYVRV
ELNTSRDVVF AFDVGNGDEN LTVHSDDFEF NDDEWHLVRA EINVKQARLR VDHRPWVLRP
MPLQTYIWLE YDRPLYVGSA ELKRRPFVGC LRAMRLNGVT LNLEGRANAS EGTSPNCTGH
CAHPRFPCFH GGRCVERYSY YTCDCDLTAF DGPYCNHDIG GFFEPGTWMR YNLQSALRSA
AREFSHMLSR PVPGYEPGYI PGYDTPGYVP GYHGPGYRLP DYPRPGRPVP GYRGPVYNVT
GEEVSFSFST QSAPAVLLYV SSFVRDYMAV LIKEDGTLQL RYQLGTSPYV YQLTTRPVTD
GQPHSVNITR VYRNLFIQVD YFSLTEQKFS LLVDSQLDSP KALYLGRVME TGVIDPEIQH
YNTPGFSGCL SGVRFNNVAP LKTHFRTPRP MTEELAEALR VQGELSESNC GAMPRLVSEV
PPELDPWYLP PDFPYYHDDG WVAILLGFLV AFLLLGLVGM LVLFYLQNHR YKGSYHTNEP
KATHDYHAGS KPPLPTSGPV PAPAPASAPT PTPASTQVPA PAPAPAPAPA PGPRDQNLPQ
ILEESRSE
//
