ID F1MLY5_BOVIN Unreviewed; 1095 AA.
AC F1MLY5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=MLLT6, PHD finger containing {ECO:0000313|Ensembl:ENSBTAP00000015325.6};
GN Name=MLLT6 {ECO:0000313|Ensembl:ENSBTAP00000015325.6,
GN ECO:0000313|VGNC:VGNC:31504};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000015325.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000015325.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000015325.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000015325.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000015325.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1MLY5; -.
DR SMR; F1MLY5; -.
DR STRING; 9913.ENSBTAP00000015325; -.
DR PaxDb; 9913-ENSBTAP00000015325; -.
DR Ensembl; ENSBTAT00000015325.6; ENSBTAP00000015325.6; ENSBTAG00000011532.6.
DR VEuPathDB; HostDB:ENSBTAG00000011532; -.
DR VGNC; VGNC:31504; MLLT6.
DR eggNOG; KOG0956; Eukaryota.
DR GeneTree; ENSGT00940000158572; -.
DR HOGENOM; CLU_010286_1_0_1; -.
DR InParanoid; F1MLY5; -.
DR OMA; EKHPAHH; -.
DR TreeFam; TF316118; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000011532; Expressed in thymus and 104 other cell types or tissues.
DR ExpressionAtlas; F1MLY5; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:Ensembl.
DR GO; GO:0035811; P:negative regulation of urine volume; IEA:Ensembl.
DR GO; GO:0010765; P:positive regulation of sodium ion transport; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0036359; P:renal potassium excretion; IEA:Ensembl.
DR GO; GO:0035812; P:renal sodium excretion; IEA:Ensembl.
DR GO; GO:0070295; P:renal water absorption; IEA:Ensembl.
DR CDD; cd15709; ePHD_AF17; 1.
DR CDD; cd15574; PHD_AF10_AF17; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049781; AF10/AF17_PHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF90; PROTEIN AF-17; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 5..57
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 62..181
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 117..180
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 186..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 721..755
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 204..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..390
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..866
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 112205 MW; 9AD34202D44849A4 CRC64;
MKEMVGGCCV CSDERGWAEN PLVYCDGHAC SVAVHQACYG IVQVPTGPWF CRKCESQERA
ARVRCELCPH KDGALKRTDN GGWAHVVCAL YIPEVQFANV LTMEPIVLQY VPHDRFNKTC
YICEEQGRES KAASGACMTC NRHGCRQAFH VTCAQMAGLL CEEEVLEVDN VKYCGYCKYH
FSKMKTSRHS SGGGGGSGGT GGGGGSTGGG SSSFIAGRRS RSASPSAQQE KHPSHHERGQ
KKSRKDKERL KQKHKKRPES PSILTPPVVP TADKVSSSAS SSSHHEASTQ ETSEGSRDSK
GKKSSSHSLS HKGKKLSSGK GVSCFTSASS SSSSSSSSSS GGPFQPTVSS LQSSPDFSAF
PKLEQPEEDK YSKPTAPPPS APPSPSAPEP PKADLFEQKV VFSGFGPIMR FSTTTSSSGR
ARAPSPGDYK SPHVSGSGAS GGTHKRMPTL SATPVPAEET PETGLKEKKH KASKKSRHGP
GRPKGSRNKE GPGGPALPSL PGAQLAGFTA TAASPFSGGS LVSSGLGGLA SRTFGPSGSL
PSLSLESPLL GAGIYTSNKD PISHGGGMLR AVCSTPLSSS LLGPPGTSAL PRLSRSPFTS
TLPSSSASIS TTQVFSLAGS TFSLPSTHIF GTPMGAVNPL LTQAESSHTE PDLEDCSFRC
RGTSPQESLS SMSPISSLPA LFDQTASAPC GGGQLDPAAP GTTNMEQLLE KQGDGEAGVN
IVEMLKALHA LQKENQRLQE QILSLTAKKE RLQILNVQLS VPFAALPAAL PATNGPVPGP
YGLPPQAGSS DSLSTSKSPP GKNSLGLDNS LSTSSEDPHS GCPSRSSSSL SFHSTPPPLP
LLQQSPATLP LALPGGPAPL PPQPQNGLGR APGAAGLGAM PMAEGLLGGL AGSGALPLNG
LLGGLNGAAA PNPAGLSQAG GAPTLQLPGC LNSLTEQQRH LLQQQEQQLQ QLQQLLASPQ
LTPEHQTVVY QMIQQIQQKR ELQRLQMAGG SQLPMASLLA GSSTPLLSAG TPGLLPTASA
PPLLPAGALV APSLGNNTSL MAAAAAAAAV AAAGGPPVLT AQTNPFLSLS GADGSASGPK
GGTADKGASA NQEKG
//
