ID   F1MTS9_BOVIN            Unreviewed;       616 AA.
AC   F1MTS9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=Tetratricopeptide repeat protein 39B {ECO:0000256|ARBA:ARBA00015483};
GN   Name=TTC39B {ECO:0000313|Ensembl:ENSBTAP00000032361.4,
GN   ECO:0000313|VGNC:VGNC:36476};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000032361.4, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000032361.4, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000032361.4,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000032361.4}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000032361.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TTC39 family.
CC       {ECO:0000256|ARBA:ARBA00006400}.
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DR   RefSeq; XP_002689625.3; XM_002689579.5.
DR   RefSeq; XP_585202.5; XM_585202.8.
DR   AlphaFoldDB; F1MTS9; -.
DR   STRING; 9913.ENSBTAP00000032361; -.
DR   PaxDb; 9913-ENSBTAP00000032361; -.
DR   Ensembl; ENSBTAT00000032429.4; ENSBTAP00000032361.4; ENSBTAG00000003943.5.
DR   GeneID; 508428; -.
DR   KEGG; bta:508428; -.
DR   CTD; 158219; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003943; -.
DR   VGNC; VGNC:36476; TTC39B.
DR   eggNOG; KOG3783; Eukaryota.
DR   GeneTree; ENSGT00950000182917; -.
DR   HOGENOM; CLU_010086_3_0_1; -.
DR   InParanoid; F1MTS9; -.
DR   OrthoDB; 5477282at2759; -.
DR   TreeFam; TF313761; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000003943; Expressed in semen and 100 other cell types or tissues.
DR   ExpressionAtlas; F1MTS9; baseline and differential.
DR   GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0010887; P:negative regulation of cholesterol storage; IBA:GO_Central.
DR   GO; GO:0010874; P:regulation of cholesterol efflux; IBA:GO_Central.
DR   GO; GO:0090181; P:regulation of cholesterol metabolic process; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR31859; TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER; 1.
DR   PANTHER; PTHR31859:SF4; TETRATRICOPEPTIDE REPEAT PROTEIN 39B; 1.
DR   Pfam; PF10300; Iml2-TPR_39; 1.
DR   Pfam; PF13174; TPR_6; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REGION          37..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   616 AA;  70419 MW;  0EA8B17EDEA207BE CRC64;
     MALVGNGAEL EVDEDIFEDA LETLSVPSRV DMATSSQHFS SFDSKQAPGQ PRTSNVKRSL
     STKVDLRSGL EECAIALNLF LSNKFTDALE LLRPWAKESM YHALGYSTIV VLQAVMTFEQ
     QDIQNGISAM KDALQTCQKY RKKCTVVESF SSLLSRGSLE QLTEEEMHAE ICYAECLLQK
     AALTFVQDEN MINFIKGGLK IRTSYQIYKE CLSILHVIQK NKVEQQFFYE FEGGVKLGIG
     AFNLMLSLLP ARIIRLLEFI GFSGNRELGI LQLREGALGR SIRSPLCCLT ILAFHTYISL
     ILGTGEVNVV EAESLLEPYL QQFPNGSLVL FYHGRIELLK GNVEEAQEIF RKCISVQEEW
     KQFHHLCYWE LMWIFVFQQN WREAYYYSDL LCKESRWSKA TYVFLKAAIL SMLPEEDVVA
     TKEDVVTLFR QVDGLKQRIA GKSIPTEKFA VRKARRYSPS LPVPVKLVLP ALEMMYVWNG
     FPLVSKRKDL SENLLVTVEK AEAALQSENS SDYSVDDDCL VKLLKGCCLK NLQRPLQAEL
     CFNHIIQSEK LLKYDHYLVP FTLFELAFLY KNQGEIDKAI KVLETARNNY KDYSLESRLH
     FRIQAALHLW KKSSSD
//