ID F1MV07_BOVIN Unreviewed; 1032 AA.
AC F1MV07;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=SEC24 homolog D, COPII coat complex component {ECO:0000313|Ensembl:ENSBTAP00000004721.5};
GN Name=SEC24D {ECO:0000313|Ensembl:ENSBTAP00000004721.5,
GN ECO:0000313|VGNC:VGNC:34416};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000004721.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000004721.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000004721.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000004721.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000004721.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR RefSeq; XP_002688104.1; XM_002688058.4.
DR RefSeq; XP_015319175.1; XM_015463689.1.
DR AlphaFoldDB; F1MV07; -.
DR SMR; F1MV07; -.
DR STRING; 9913.ENSBTAP00000004721; -.
DR PaxDb; 9913-ENSBTAP00000004721; -.
DR Ensembl; ENSBTAT00000004721.6; ENSBTAP00000004721.5; ENSBTAG00000003619.6.
DR VEuPathDB; HostDB:ENSBTAG00000003619; -.
DR VGNC; VGNC:34416; SEC24D.
DR eggNOG; KOG1984; Eukaryota.
DR GeneTree; ENSGT00950000182924; -.
DR HOGENOM; CLU_004589_1_1_1; -.
DR InParanoid; F1MV07; -.
DR OMA; QNGAHAS; -.
DR TreeFam; TF300464; -.
DR Reactome; R-BTA-204005; COPII-mediated vesicle transport.
DR Reactome; R-BTA-2132295; MHC class II antigen presentation.
DR Reactome; R-BTA-5694530; Cargo concentration in the ER.
DR Reactome; R-BTA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000003619; Expressed in saliva-secreting gland and 107 other cell types or tissues.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR PANTHER; PTHR13803:SF6; PROTEIN TRANSPORT PROTEIN SEC24D; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 360..398
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 437..680
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 686..769
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 782..881
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 900..974
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..96
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..182
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1032 AA; 112459 MW; B627725DF2980CC9 CRC64;
MSQQVYVATP PYSQSQPGIG LSPPHYGHYG DPSHAGSPPG MIKPAGPLGA APPGGMLPQG
HPPPGPHQFG QNGAHAQGPP PQRFPGPPPV NSAAPAYPPY SPSTQSSYPS PGSTSSVAQL
GSQLNAMHIN SYGSGVAPPS QGPPGPVSAA SFQGPPQPPQ PSILQPGSQI LPPPPTALNG
PGASPLPPST HRADGLPGPA PPNAQYQPTP LPGQTLGPGY PAQQANYGPP VAGAQLSYPG
GFPGGPAQMA GPPQPQKKLD PDSVPSPIQV IESDRATRGG QVYATNARGQ IPPLVTTDCV
IQDQGNASPR YIRCTTYCFP CTSDMAKQAQ IPLAAIIKPF ATIPSNETPL YLVNHGEAGP
VRCNRCKAYM CPFMQFIEGG RRYQCGFCSC VNDVPPFYFQ HLDHIGRRLD HYEKPELSLG
SYEYVATLDY CRKNKPPNPP AFIFMIDVSY SNIKNGLVKL ICEELKTVLE KLPKEDQEET
SAIRVGFITY NKVLHFFNVK SNLAQPQMMV VTDVSEVFVP LLDGFLVSYR ESQSVIHNLL
DQIPEMFADS NENETVFAPV IQAGMEALKA ADCPGKLFIF HSSLPTAEAP GKLKNRDDKK
MINTDKEKIL FQPQTNIYDS LAKDCVAHGC CVTLFLFPSQ YVDVASLGLV PQLTGGTLYK
YNSFQMHLDS QQFLNDLRND IEKKIGFDAI MRVRTSTGFR ATDFFGGIYM NNTTDVEMAA
IDCDKAVTVE FKHDDKLSED TGALIQCAVL YTTVSGQRRL RIHNLGLNCS SQLADLYKSC
ETDALINFFA KSAFKAVLHQ PLKVIREILV NQTAHMLACY RKNCASPSAA SQLILPDSMK
VLPVYMNCLL KNCVLLGRPE ISTDERAYQR QLVMTMGVAD SQLFFYPQLL PIHTLDVKST
TLPAAIRCSE TRLSEEGIFL LANGLNMFLW LGVSSPPELI QGIFNVPSLA HVNTDMTLLP
ELGNPYSQTL RMIMGIIQQK QPYSMKLTIV KQREQPEMVF RQFLVEDKGL YGGSSYVDFL
CCVHKEICQL LN
//
