ID F1N0A6_BOVIN Unreviewed; 6307 AA.
AC F1N0A6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Adhesion G protein-coupled receptor V1 {ECO:0000313|Ensembl:ENSBTAP00000007926.6};
GN Name=ADGRV1 {ECO:0000313|Ensembl:ENSBTAP00000007926.6,
GN ECO:0000313|VGNC:VGNC:25673};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000007926.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000007926.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000007926.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000007926.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000007926.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 9913.ENSBTAP00000007926; -.
DR PaxDb; 9913-ENSBTAP00000007926; -.
DR Ensembl; ENSBTAT00000007926.6; ENSBTAP00000007926.6; ENSBTAG00000006031.6.
DR VEuPathDB; HostDB:ENSBTAG00000006031; -.
DR VGNC; VGNC:25673; ADGRV1.
DR eggNOG; KOG1306; Eukaryota.
DR GeneTree; ENSGT00940000154880; -.
DR HOGENOM; CLU_223063_0_0_1; -.
DR InParanoid; F1N0A6; -.
DR OMA; RYTAFEV; -.
DR TreeFam; TF331149; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000006031; Expressed in myometrium and 88 other cell types or tissues.
DR ExpressionAtlas; F1N0A6; baseline.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0032420; C:stereocilium; IBA:GO_Central.
DR GO; GO:0010855; F:adenylate cyclase inhibitor activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0071277; P:cellular response to calcium ion; IBA:GO_Central.
DR GO; GO:0048496; P:maintenance of animal organ identity; IEA:Ensembl.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.2030; -; 36.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR026919; ADGRV1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009039; EAR.
DR InterPro; IPR005492; EPTP.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR006558; LamG-like.
DR PANTHER; PTHR46682; ADHESION G-PROTEIN COUPLED RECEPTOR V1; 1.
DR PANTHER; PTHR46682:SF1; ADHESION G-PROTEIN COUPLED RECEPTOR V1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF03160; Calx-beta; 31.
DR Pfam; PF03736; EPTP; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SMART; SM00237; Calx_beta; 18.
DR SMART; SM00560; LamGL; 1.
DR SUPFAM; SSF141072; CalX-like; 38.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50912; EAR; 6.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..6307
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018675344"
FT TRANSMEM 5909..5929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5941..5960
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5980..6000
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 6012..6037
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 6057..6081
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 6108..6125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 6131..6156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 3255..3296
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3297..3345
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3348..3393
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3395..3439
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3441..3488
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3492..3534
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT DOMAIN 5906..6157
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 6218..6249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6273..6292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6218..6245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6273..6291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6307 AA; 690794 MW; 61C388100252D2A0 CRC64;
PSFFLSPWMP SASLLVNLLS ALFIPFVFGE TEIRFAGQTE FVVNETSTTV IRLVVERIGD
PANVTAIVSL YGDDTGDFFD TYAATFIPFG ETSRTVYIAV CDDDFPEPDE TFIFHLTLQK
PSANVKLGWP RTVTVTILSN DNAFGIISFN MPFSITVSEP RGRNESVPLT LIREKGTYGM
VTVTFEVEGG PNPPEEDLSP VKGNITFPAG KATVVYNLTV LDDEVPENDE IFLIQLKSVE
GGAEINTSRS SVEIIIKKND SPVRFIQNVY LVPEEDHILT IPVVRGKDDS GNLIGSDDCE
VSISYVIITG NSTAHAQQNL DFIDLQPNTT IVFPPFIYES HLKFQIVDDA IPEIAESFQV
VLLKDTLRGD AVLFGPSVVQ VTIKPNDKPY GVLSFNSVLF ERPVIIDEDT TTRFEEITVV
RNGGTHGNVS VNWVLTRNSS DPSPVTTDIR PRSGVLHFAQ GQMLASIPLI VVNDDLPEEA
EAYLLQILPH TIRGGAEVSE PAELLFYIQD SDDVYGLITF FPVENQKIES SPGERCLSLS
LTRLGGTKGD VKIFYSALYI PAGAVDPLRA KDGILNISKR SSLIFPEQKT QVTIKLPIRN
DAFLQNGAHF LVQLEAVELV NIVPPIPPIS PRFGEIQNIS LVVTPDIANG EIGFISNLPI
ILHEPEDFAA EVVCIPLHRD GTDGQATVYW SLKPSGFNSK AVTLDDIGPF NGSVVFLSGQ
SDTTINITVK ADDIPEMNET VTLSVDRVSV ENQVLKSGYT SRDLIILEND DPGGVFEFSS
ASRGPYIIKE GESVELHIIR YRGALVKQFL HYRIEPRDSN EFYGNTGVLE FKPGEREIVI
TLLSRLDGIP ELDEHYWVVL TSHGERESKL GSATVVNITI LKNDDPHGII EFVSDDLIVT
INESKGDNTC SAVYGVIRNR GTFGDVNVSW VVSPDFTHDV FPVRGTIFFG DQEFLKNITI
YSLPDEIPEE MEEFTITLLN ATGGAKIGNI TTATLRIRRN DDPIYFAEPR VVRVREGETA
DFKVLRNGSV DVPCTVQYAT MDGEATAREG DFVPIEKGEM LVFTVGSREQ NISVFIMEDD
IPETDEPFYI ILFNSTGDTV VYPYATATVI IEANDDPNGI FALEPIDKAV EEGKTNSFWI
LRHRGHFGNV SVAWQLFQND SALQLGQEFY ETSGTVNFLD GEGAKPIILH AFPDKIPEFN
EFYILKLVNI SGGSPGPGGQ LAATNLQVTV MIPFNDDPFG VFILDPECLE REVAEDVLSE
DAMSYITNFT ILRQQGAFGD VRVGWEILSS EFTAGLPPVT DFLLAGIFPS SVHLQPHMRR
HHSGTDALYF SGLEGAFGTV NPKYHPSRNN SIANFTFSAW VMPNPNTNGF VIAKDDGNGG
IYYGVKIHTN ESHVTLSLHY KTLGSNATYV AKTTVMKYLE ENVWLHLLIV LDDGIIEFYL
DGNAMPRGIK SLKGEAITDG PGTLRIGAGV NGNDRFTGLM QDVRSYEQKL TLEEIYELHA
MPAKSDLHPV SGYLEFREGE TNKSFIISAR DDNEEEGEEL FILKLVSVYG GARLSEENTT
ARLVIQKSDN ANGLFGFTGA CIPEIAEEGS TISCVVERTR GALDYVHVFY TISQIESDGV
NYLVDDFANA SGSITFLPWQ RSEVLNIYVL DDDIPELNEY FRVTLVSAIP GDGKIGSTPT
SGASIDPEKE TTDITIKASD HPYGLLQFST GPPPQPEDTM TLPASGVPHV TVREEDGEVR
LLVVRAQGLL GRVMAEYRTV SLTAFSPEDY QSVAGTLEFQ PGERFKYISV NITDNSIPEL
EKSFKVELLN LEGGVTELFR VDGSGSGDGD MEVFLPANRR HAGLGVASQI LVTIAASDHA
HGVFEFSPES LVVSGTEPED GYSTVIFNIM RSHGALSRVT LLWSIDSDPD GDLAFTSGNV
TFEIGQKRAN ITVEILPDED PELDKAFSVT ILSVSSGSLG VHTNATLIVL ASDDPYGVFI
FSEKNRPIKV EEATQNITLS IIRLKGLLGK VKVTYATLDD MEKLPHFPPN LARATQGKDY
LPASGFAVFR ANQSEATITV SVLDDDEPER SESLFVELLN STLTEKVQNR PIPNSPRLGP
KVEAIAELII IANDDAFGTL QLSAPVVRVA ENHVGPIINV TRTGGTFADV SVKFKAVPIT
AVAGEDYSIA SSDVVLLEGE TSKAVPIYII NDIYPELEES FLVQLLNETT GGAKLGALTE
AIIIIEASDD PYGLFGFQIT KLIVEEPEFN SVKVNLPIIR NSGTLGNVTV QWVATINGQL
ATGDLRVVSG NVTFAPGETI QTLLLEVLAD DVPEIEEVIQ VQLTDASGGG TIGLDRVANI
IIPANDNPYG TVAFVQSVSR VQEPLERSSC ANITVRRSGG HFGRLLLFYG TSDIDVVALA
VEEGQDLLSY YESPIQGLPD PLWRTWVNVS AMGEPQDTCA TLCLKEHACS AFSFLSASEG
PQCFWMTSWA SPTANNSDFW TYKKNVTRVA SLFSGQAVAG SDYEPVTRQW AIMLEGDEFA
NLTVSILPDD FPEMDESFLI SLLEVHLMNI TASFKNQPTI GQPNTSTVVI ALNGDAFGVF
VIYSISPNTS EDGLYVEVQE QPQSTVEMVI HRTGGSLGQV TVEWRVVGGT ATEGLDFIGA
GDILTFAEGE TKKVAVLTIL DDSEPEDDEI IVVSLVYTEG GSRILPSSDT VRVNILANDN
VAGVVGFQTT SRSVIGPEGE ILQFHVIRTP PGRGNVTVNW KIIGQNLEFN FANSTGQLFF
PEGSLNKTIS VHLLDDNIPE EKEVYQVILY DVRTQGVSPA GAALLDAQGY AAVLTVEASD
EPHGVLNFAL SSRFVLLQEA NTTVKLFINR EFGSLGAVNV TYATVPGMLS RKNQTEGNLA
EPDVDFVPVV GFLILEEGET AGAIDITILE DDIPELEEYF LVNLTHVELI MAPFTSFPPR
LDSEGLTAQI IIDANDGARG IIEWRQSRFE VNETQGSLTL VAQRRTGALG HVSLFVYAQN
LEAQLGVDYA FTPMILHFAN GERYKNVDIM ILDDDIPEGD EAFQLILTNP SPGLELGENI
IAFVTILAND DGPGVLSFNN SEHFFLREPT AVYIQESMAV LYVIREPAQG LFGTVTVQFI
VTEVNSSMES KDLTPSKGYV VLEEGVRFKA LHISAILDTE PEMDEHFVCT LFNPTGGARL
GAHVQTLITV LQNQAPLGLF SISAVANRAT SVSIEEANRT VYLSVSRTNG IDLAVSVEWE
TVSETAFGMR GMDVMFSMFQ SFLEASASGW CFFTLEDSVH GLMLRKLSST LYRWQGIFVP
FEDLSIENPK TCEAFNIGLS PYFVITHEER NEEKSSVNSV YTFTSGFKLF LVQRINISES
SQVRYFTSDS QDYLIVASQS DDSQLTQVFR WNGGSFVWHQ TLSVRGVLSM ALFTRGGAVF
LAIAQANARS NSLLLRWSSN EFTNFQEVPI SGTTQVEALT SGDDIYLIFA KAIFLGDQNS
VDIFVWEAGQ SSFRYFQSLD FAAVNKIHSF TAASGIVHLL LLGQAVSALY CWNSELNHFS
FLLEAPSAYD AAFVTVKSLN SSKNLIALAG ATHSHIYELA YVSSQSDFIP SSGELIFEPG
DKEAIIAVNV LDDTVPEEDE SFRVQLKNPK GGAEIGINGY VQITILSNDD AYGVVGFAQN
SLYKQVEEME QDSLVTLNVE RLKGTYGRIT VAWEADGSIS DIFPTSGVIS FSEGQALSTI
TLTVLADDLP ELSEIVIVTL IRIITEGVED PSKGATIDQK RNKSVITTLP NDSPYGLVGW
HAESLFIKVA EPKENVTALQ LQIVRDKGLL GDIAIQLVAK PNFLLHINNQ ATENKDYVLQ
ETMIIMKENI KETYVKVAIL PDDVPELEEG FIVSITEVRL VNSDFSAGQP SVRRPGLEMA
EIMIEENDDP RGIFKFHVTR DVGVITAYEV PPPLNVLQIP VVRLAGSFGA VKVYWKATVD
SAGLEDFKPS HGILEFADRQ VTAVIEITII DDDEFELLEM FNISLIKAAG GGRLGDDVVV
TVVIPQNDSP FGVFGFEEKT VMVDESLLSD DPDSYVTLTV VRSPGGKGAV RLQWTLDEMA
KDDLSPLSGT LHFNETESQK TIVLHTLQDA TLEEDRRFTI QLLSVDEVEI SPVKGSASII
IRGDKGASGE VGIAPSSRHV LIGEPSAKYN GTAIISLIRG PAISGEVTVS WRIVPPSLEE
FAETSGKLTM RDGQSAAVVV IQALNDDLPE EKRFYEFQLT EVSEGGVLSE SSTTATITVV
ASDFPYGRFA FSQEQLRVTE EIQKVNLTVI RSGGSFGRVR LCLEAVSGTA EVGVDFLPPP
VQLLFEAKET VKIVHIEILD DSLPEGPEEF SLMMTEVELL GRGYDFTIQE NGLQIDQPPE
IGNISIVRII IMKNDNAEGI IEFDPRYTTF EVEEDIGTIM IPVQRLHGTY GRVTADFVSQ
SSSAVPGGVD YVLHGSSVTF QHGQNLSFIN VSIIDDDESE FEEPIEIMLI GATGGAVLGR
HLVCRITIAK SDSPFGVIRF LNQSRVSVPN PNSTMILPLM LERTGGLLGE IQVNWEIVGP
NSQEALPSQN RDIADPVSGS FSFGDGEGGM RSIILVIYPH DDIEIEKTFI IKLELVRGEA
QLDSTANDVT LTIEKFGDPN GVIQFAPESL SEETYLEPST LEGPLIITFF VRRIKGVSGE
IMVYWELSSE FDITGDFLST KGSFTIADGE SEASFDVHLL PDDIPEIEEV YVLQLVLVKG
GAKLDTEKCV IRFSVSANDD PHGIFALYSD HQSILIGQNL RRFIQINVTR LAGTFGDVAV
RYRISSDSKE QSVVTENAER QLVVRDGTRY KVDSVPVQSQ VFLPLGSNFT LQLVTVMLVG
GSFYGVPKIL QEAKSAVLPV PEKAANSQVG FEFTAFPLTD IAAGTSQAVI SRRGTYGSLK
VSWAAGYVPG SEIPEFTTVG NMTPKVGELS FSHGEESKRV LLWTHPSPGR LEAFVVHLSG
VQSSVPGGAQ LRSGFTVAEI EPMGVFQFSP SSRNIIVSED TQMIRLHVQR LFGFHGELIK
VSYQTAAGRA KPQKDFEPVQ NGELLFQKFQ VEVDFEIIII DDELPEIEEI FYINLTSVEI
QGLPKFDANW RPRLNQDFSV AVITILDNDD LAGTDTSFTK TAVTTAVDTA LPLETDSATT
HPDTTEITAI PQPTEVVAVV TEVAGVPPIP ENLVTLAGTS ATSEKPNAAT VTTDTSVHGT
FSLGPPVVYI EEEMENGTLN AAEVLVRRTG GSAGNVSVTV RTFGERSAQK EPNTLPFPDR
HGISNLTWAT EEEDFKAQTL ILAFVDGERE RKVSIAILDD GDPEGQEFFY VFLTDPQGGA
QIVKGEDDAG FADFAMIIIT GSDLHNGIIG FSEESQSRLE LGEETETSSL HLTVTRQPNR
AFEDVEVFWR VTFNKTAAVL QKDGVNLADE LLSVSGTTVC RAGQTECFIS IELKPGKIPQ
SEIHFFVELY EVTAGAALNN SARFAQIKLL QRDKPPSLVY FSVGSRLPVA HKKATLISLQ
VARDYGAGLM MSVNFSTQEL RSAETIGRTL ISPAISGKDF VRTEGTLIFE PGQRTTVLDV
ILTPETGSLN PFPKRFQIVL FDPRGGARVD KVYGTANITL VSDANSQAFW GLADQLQQPL
DGDILNRVLH SVSVKVATEN TDEQLSAVLY LIDKITVEGK NQALSIESRN LFYEILCALV
NPKRKDTRGF SHFTEVTENF AFSLLTDVTC GSPGEKGKTI LDSCPYLSIL ALHWYPQQIN
GHKFEGKEGD YIRVPERLLD VLDAEIMAGR STCELVQFTE YSSQQWFMTG NNFHALKNKV
LSLSVKGQSS QPLTNSNEIL YRIYAAEPRI VPKTPLCLLW NPAAASWLSD SQFCKVVEDT
SDYVECACSY MSVYAVYAQT DNLSSYNEAF FSSGFICISG LCLAVLSHIF CARYSMFAAK
LLTHMLAASL GTQIVFLASA YASPRLTEES CSAIAAVTHY LYLCQFSWML IQSVNFWYVL
VMNDEHTERR YLLFLLLSWG LPALVVVLLI VILRAAYHQS MPQIYGLIHG DLCFIPNIYA
ALFTAALVPL MCLVVVFVVF IHAYQVKPQW KAYDDVFRGR TNAAEIPLVL YLFALISMTW
LWGGLHMAYR LFWMLVLFVI FNSLQGLYVF VVYFILHNQT CCPMKASYTV EMNGHPGPST
AFFTPGSGMP AAGGEISKST QNLISAMEEV PPDWERASFQ QASQASPDLK PSPQNGATFP
SSGGYGQGSL IADEESQEFD DLIFALKTGA GLSVSDNESG QGSQEGGTLT DSQIVELRRI
PIADTHL
//
