ID F1QMI7_DANRE Unreviewed; 574 AA.
AC F1QMI7; A0A8M1NBT4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Ceramide kinase {ECO:0000313|RefSeq:NP_001074148.2};
DE EC=2.7.1.138 {ECO:0000313|RefSeq:NP_001074148.2};
DE SubName: Full=Zgc:158263 {ECO:0000313|Ensembl:ENSDARP00000036893};
GN ORFNames=zgc:158263 {ECO:0000313|Ensembl:ENSDARP00000036893,
GN ECO:0000313|RefSeq:NP_001074148.2,
GN ECO:0000313|ZFIN:ZDB-GENE-070112-2262};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000036893};
RN [1] {ECO:0000313|RefSeq:NP_001074148.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001074148.2};
RX PubMed=12477932; DOI=10.1073/pnas.242603899;
RG Mammalian Gene Collection Program Team;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D.,
RA Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F.,
RA Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H.,
RA Moore T., Max S.I., Wang J., Hsieh F., Diatchenko L., Marusina K.,
RA Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F.,
RA Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S.,
RA Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J.,
RA Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J.,
RA Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M.,
RA Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C.,
RA Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Krzywinski M.I.,
RA Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human and
RT mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000036893}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000036893};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000036893, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000036893};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_001074148.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001074148.2};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [5] {ECO:0000313|RefSeq:NP_001074148.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001074148.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR855310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001074148.2; NM_001080679.2.
DR STRING; 7955.ENSDARP00000036893; -.
DR PaxDb; 7955-ENSDARP00000036893; -.
DR Ensembl; ENSDART00000035080; ENSDARP00000036893; ENSDARG00000037267.
DR Ensembl; ENSDART00000035080.7; ENSDARP00000036893.6; ENSDARG00000037267.6.
DR GeneID; 791197; -.
DR KEGG; dre:791197; -.
DR AGR; ZFIN:ZDB-GENE-070112-2262; -.
DR ZFIN; ZDB-GENE-070112-2262; zgc:158263.
DR eggNOG; KOG1115; Eukaryota.
DR HOGENOM; CLU_013399_2_2_1; -.
DR OMA; WDTHPLS; -.
DR OrthoDB; 7645at2759; -.
DR PhylomeDB; F1QMI7; -.
DR TreeFam; TF314514; -.
DR Proteomes; UP000000437; Chromosome 23.
DR Bgee; ENSDARG00000037267; Expressed in zone of skin and 17 other cell types or tissues.
DR GO; GO:0001729; F:ceramide kinase activity; IBA:GO_Central.
DR GO; GO:0006672; P:ceramide metabolic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR045363; CERK_C.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF95; CERAMIDE KINASE; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF19280; CERK_C; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|RefSeq:NP_001074148.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transferase {ECO:0000313|RefSeq:NP_001074148.2}.
FT DOMAIN 125..275
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 574 AA; 64018 MW; 458D1AE69318A678 CRC64;
METDMDSVRV ESSLWIGNKR YRAFLSGWYF SWTEIDKGNR EKKTISVPVS EVIGVKEGRV
EIQPQKKVED TDLDFTLFHV NRNSRGNAQG LTWSLGRTQF CCPSRAVRDQ WITQHRTALK
THSPSRPHRL LVFINPFGGK KRGKQIFHSL VSPLFELAGI SSHVVVTERA NQARDYILKK
DLTGFDGVIC VGGDGMFSEL LHGVIGRTQQ EAGVSENDLT AMLQPCDLHI GVIPAGSTDC
VCFTTVGIND PVTSALHIII GDSQPLDVCS VHDQSTVVRY SVSLVGYGFY GDVLEESERH
RWMGPLRYDY AGCMVYMCNR SYSGLVQYLP SDSQISSPRD NTRCLSGCRV CSESKERLFP
HFDSSTSLYS SNVSQYSTEL EGEWVTVEGT FKCISLTCVS SSCPRSPKGL SPSAHLADGT
ADLILVRDTN PLSFLTYLHR HTNKQDQFDL PFVEVHRVKA VRFSLPPGEE EDFEEEEEKI
QSSAERVLED PGKLCSNNIA GHSQQHLTGQ KEKATSTSRL KRPGFVCGPC CTKPRSVSVW
NCDGEILPQT EISCRIHGQL VRLFARGIED STRA
//
