ID F1QXF9_DANRE Unreviewed; 644 AA.
AC F1QXF9; A0A8N7UVH9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Interferon-induced GTP-binding protein Mx3 isoform X1 {ECO:0000313|RefSeq:XP_695562.6};
DE SubName: Full=Myxovirus (influenza virus) resistance D {ECO:0000313|Ensembl:ENSDARP00000035196};
GN Name=mxd {ECO:0000313|Ensembl:ENSDARP00000035196,
GN ECO:0000313|RefSeq:XP_695562.6, ECO:0000313|ZFIN:ZDB-GENE-030721-8};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000035196};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000035196}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000035196};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000035196, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000035196};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_695562.6}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_695562.6};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR EMBL; CU041386; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU062667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_695562.6; XM_690470.9.
DR STRING; 7955.ENSDARP00000035196; -.
DR PaxDb; 7955-ENSDARP00000035196; -.
DR Ensembl; ENSDART00000036702; ENSDARP00000035196; ENSDARG00000023369.
DR Ensembl; ENSDART00000036702.5; ENSDARP00000035196.3; ENSDARG00000023369.6.
DR GeneID; 360146; -.
DR AGR; ZFIN:ZDB-GENE-030721-8; -.
DR CTD; 360146; -.
DR ZFIN; ZDB-GENE-030721-8; mxd.
DR eggNOG; KOG0446; Eukaryota.
DR HOGENOM; CLU_008964_8_0_1; -.
DR OMA; INIIDEM; -.
DR OrthoDB; 4116505at2759; -.
DR PhylomeDB; F1QXF9; -.
DR TreeFam; TF331484; -.
DR Proteomes; UP000000437; Chromosome 25.
DR Bgee; ENSDARG00000023369; Expressed in granulocyte and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF225; INTERFERON-INDUCED GTP-BINDING PROTEIN MXA-RELATED; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003932};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 61..345
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 558..644
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
SQ SEQUENCE 644 AA; 73656 MW; 2847EF230E994F28 CRC64;
MTWWQKEASA IEPEKEIIKQ HGLRGRTRKG MEGEFHHHLD ENIRPYIDLI DTLRSVGVQN
EVSLPTIVVI GDQSSGKSSV LEALSGVALP RGSGIVTRCP LELRLRKVTG VKWKAVLTYR
SVKSRPDKQG NNLKTFEFED SSIVEKHVTD AQNELAGKGV GICDDLITLE VMSKDVCDLT
LIDLPGIVRV PVAGQPEDVG DQIKRLIMKY IMKRETINLV VVPCNIDIAT TEALRMAQNV
DPEGIRTVAI LTKPDLIDKG TEKGILKVVQ NKVIHLRKGY TMVKCRGQQQ INDRITLEEA
LEEEKEFFQN HDTFRCLLSE NKATIKCLAV KLTKDLVDHI KNSLQRVDDQ VKKLLWDVKN
ELKECEGGPP QDPKGAKQFL IKTIKKFNDI VTSMSSGELM LNENLFAELR GEFKKWNDHL
EQKKSPFNYS KELMKKNRGR ELHGFSNYKL FETILQDHVA QLKEPAINLL HKANGIIAKH
LTDRVSQCFR NYPALQSIAM GKAENIQSRQ QYKTEQRISE QFDMENIIYT QDSVFLKTLN
EITNERYSEE ELPLIDKACK YSHMLETYYE IVAQRLTDQL PLMIIHFMLK QTAEIMSIEM
LSLVDGTNVS KLLFEDTEVS RKRTELRARL KRLTDAQEAL NNFI
//
