ID F1R6C8_DANRE Unreviewed; 908 AA.
AC F1R6C8; A0A0R4IV39; A0A8M3B2S3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Catenin (cadherin-associated protein), delta 1 {ECO:0000313|Ensembl:ENSDARP00000096826};
DE SubName: Full=Catenin delta-1 isoform X5 {ECO:0000313|RefSeq:XP_009291712.1};
GN Name=ctnnd1 {ECO:0000313|Ensembl:ENSDARP00000096826,
GN ECO:0000313|RefSeq:XP_009291712.1,
GN ECO:0000313|ZFIN:ZDB-GENE-110208-9};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000096826};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000096826}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000096826};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000096826, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000096826};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009291712.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009291712.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
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DR EMBL; CR848663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009291712.1; XM_009293437.3.
DR Ensembl; ENSDART00000106048.4; ENSDARP00000096826.3; ENSDARG00000078233.4.
DR Ensembl; ENSDART00000166324.2; ENSDARP00000140042.2; ENSDARG00000078233.4.
DR GeneID; 556726; -.
DR AGR; ZFIN:ZDB-GENE-110208-9; -.
DR CTD; 1500; -.
DR ZFIN; ZDB-GENE-110208-9; ctnnd1.
DR HOGENOM; CLU_009111_1_0_1; -.
DR OrthoDB; 5473239at2759; -.
DR TreeFam; TF321877; -.
DR Proteomes; UP000000437; Chromosome 1.
DR Bgee; ENSDARG00000078233; Expressed in early embryo and 27 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0042074; P:cell migration involved in gastrulation; IMP:ZFIN.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR GO; GO:0008078; P:mesodermal cell migration; IMP:ZFIN.
DR GO; GO:0048920; P:posterior lateral line neuromast primordium migration; IGI:ZFIN.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR028435; Plakophilin/d_Catenin.
DR PANTHER; PTHR10372:SF6; CATENIN DELTA-1; 1.
DR PANTHER; PTHR10372; PLAKOPHILLIN-RELATED; 1.
DR Pfam; PF00514; Arm; 3.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
PE 1: Evidence at protein level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1R6C8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT REPEAT 396..424
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 439..482
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 694..736
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 29..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..908
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 100570 MW; 8F04569B9F887C49 CRC64;
MEQCENAASL LASVREQEMQ FERLTRALEE ERRSVGPSGT LPRPLPTLQN GRITGDAELE
RLKLSEGYIN GTQYRMLDPG HIVESVTVES DPHEALPIIS VETGDDGTTR RTETTVKKVT
KTTTTRTVIP SVSDTLSLDG TGSVTGMPSY NSPMDRVYRP PPGPMDYPTS TVPRNYHYGP
PAGYDDYRSV PPSEAYTSLS RGTRMDDRYR PVDGYRTLDS AYRTHSRPQL DPYSAQPQVG
RMGSAVEISA LQRFVPEPYG LEDDQRSLGY DEPDYGMGPA MHYSTMPRLA HPHHAPPPRR
TGSYEGTLDG DMSGAGDMFY WGGGAPLAQG ERGSMASLDS TLRKGPAPTA WRQPELPEVI
AMLNYRLDPV KSNAAAYLQH LTFKNDKVKS EVRRLKGIPA LVSMLDNPKK EVHYAACGAL
KNISYGRDPD NKIAIKNCDG IPALVRLLRK TRDQDLTDTI TGTLWNLSSH DSVKMEIVDH
ALHALSDEVM VPHSGWERGN EGGEESCKPR HLEWETALTN TTGCLRNVSS ERSEARRKLR
ECSGLVDSLM YIVQSQINCK DVDNKLIENS VCLLRNLSYQ VHREIPGCER YLESIPVNQG
PLPSQKGGCF SSRKGKGKRE DDGTSDTIDI PKRTTPAKGY ELLFQPEVVR VYTSLLKESK
NPSVLEAAAG AVQNLCAGRW TYGRYIRATM RQEHGLPMMT ELLSHGNDRV VRAMSGALRN
LAIDARNREL LGKHAVPNLV ANLPGGGQSQ PARALSEETV VSVLSTMAEV VGSSVDAAKT
LRSAQGIERL VLINKDSNRS DREVRGAGLV LQIVWGFKEL RRTLEKDGWK KTDFMVNLNP
PNNTRSNGGY EESTLPLIDR GGKQDREKDM IPLNDIGPDA YSTIDQRGRR NTLDDTLDRS
DRDAPQKI
//
