ID F1RJ01_PIG Unreviewed; 210 AA.
AC F1RJ01;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=High mobility group protein B2 {ECO:0000256|ARBA:ARBA00040400};
DE AltName: Full=High mobility group protein 2 {ECO:0000256|ARBA:ARBA00041514};
GN Name=HMGB2 {ECO:0000313|Ensembl:ENSSSCP00000010363.3,
GN ECO:0000313|VGNC:VGNC:88902};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000010363.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000010363.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000010363.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000010363.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the HMGB family.
CC {ECO:0000256|ARBA:ARBA00008774}.
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DR AlphaFoldDB; F1RJ01; -.
DR SMR; F1RJ01; -.
DR PeptideAtlas; F1RJ01; -.
DR Ensembl; ENSSSCT00000010639.5; ENSSSCP00000010363.3; ENSSSCG00000009704.5.
DR VGNC; VGNC:88902; HMGB2.
DR GeneTree; ENSGT00940000154466; -.
DR HOGENOM; CLU_082854_0_0_1; -.
DR InParanoid; F1RJ01; -.
DR OMA; INTCREE; -.
DR OrthoDB; 1222485at2759; -.
DR TreeFam; TF105371; -.
DR Reactome; R-SSC-140342; Apoptosis induced DNA fragmentation.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000009704; Expressed in hindlimb bud and 44 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IDA:AgBase.
DR GO; GO:0000793; C:condensed chromosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; ISS:AgBase.
DR GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:AgBase.
DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; ISS:AgBase.
DR GO; GO:0003684; F:damaged DNA binding; IEA:Ensembl.
DR GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:AgBase.
DR GO; GO:0000400; F:four-way junction DNA binding; ISS:AgBase.
DR GO; GO:0044378; F:non-sequence-specific DNA binding, bending; IDA:AgBase.
DR GO; GO:0019904; F:protein domain specific binding; ISS:AgBase.
DR GO; GO:0050786; F:RAGE receptor binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IMP:AgBase.
DR GO; GO:0097100; F:supercoiled DNA binding; IDA:AgBase.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0008134; F:transcription factor binding; ISS:AgBase.
DR GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:AgBase.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:AgBase.
DR GO; GO:0032392; P:DNA geometric change; ISS:AgBase.
DR GO; GO:0006265; P:DNA topological change; IDA:AgBase.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; ISS:AgBase.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0008584; P:male gonad development; ISS:AgBase.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; ISS:AgBase.
DR GO; GO:0010629; P:negative regulation of gene expression; ISS:AgBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IDA:AgBase.
DR GO; GO:0043388; P:positive regulation of DNA binding; ISS:AgBase.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
DR GO; GO:0045089; P:positive regulation of innate immune response; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:AgBase.
DR GO; GO:0050767; P:regulation of neurogenesis; ISS:AgBase.
DR GO; GO:0072091; P:regulation of stem cell proliferation; ISS:AgBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:AgBase.
DR GO; GO:0032496; P:response to lipopolysaccharide; ISS:AgBase.
DR GO; GO:0048545; P:response to steroid hormone; ISS:AgBase.
DR GO; GO:0007289; P:spermatid nucleus differentiation; ISS:AgBase.
DR GO; GO:0007283; P:spermatogenesis; ISS:AgBase.
DR CDD; cd21978; HMG-box_HMGB_rpt1; 1.
DR CDD; cd21979; HMG-box_HMGB_rpt2; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 2.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR017967; HMG_boxA_CS.
DR PANTHER; PTHR48112:SF3; HIGH MOBILITY GROUP PROTEIN B2; 1.
DR PANTHER; PTHR48112; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF09011; HMG_box_2; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 2.
DR SUPFAM; SSF47095; HMG-box; 2.
DR PROSITE; PS00353; HMG_BOX_1; 1.
DR PROSITE; PS50118; HMG_BOX_2; 2.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 9..79
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 95..163
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 9..79
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT DNA_BIND 95..163
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 52..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..210
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 210 AA; 24106 MW; 28E3E1409B341D83 CRC64;
MGKGDPNKPR GKMSSYAFFV QTCREEHKKK HPDSSVNFAE FSKKCSERWK TMSAKEKSKF
EDMAKSDKAR YDREMKNYVP PKGDKKGKKK DPNAPKRPPS AFFLFCSEHR PKIKSEHPGL
SIGDTAKKLG EMWSEQSAKD KQPYEQKAAK LKEKYEKDIA AYRAKGKGEA GKKGPGRPTG
SKKKSEPEDE EEEEEEEEDE DEEEEDEDEE
//
