ID F1RK75_PIG Unreviewed; 363 AA.
AC F1RK75; K0BVM3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=Septin {ECO:0000256|PIRNR:PIRNR006698};
GN Name=SEPTIN12 {ECO:0000313|Ensembl:ENSSSCP00000070639.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:AFS88928.1};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000070639.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000070639.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFS88928.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:AFS88928.1};
RA Huo J.L., Wang P., Wang S.Y., Zeng Y.Z.;
RT "Molecular cloning and expression analysis of a novel pig testis-specific
RT gene septin 12 from Chinese Banna Mini-pig Inbred Line (BMI).";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000070639.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Filament-forming cytoskeletal GTPase.
CC {ECO:0000256|PIRNR:PIRNR006698}.
CC -!- SUBUNIT: Septins polymerize into heterooligomeric protein complexes
CC that form filaments. {ECO:0000256|PIRNR:PIRNR006698}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|PIRNR:PIRNR006698, ECO:0000256|RuleBase:RU004560}.
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DR EMBL; JX477173; AFS88928.1; -; mRNA.
DR RefSeq; NP_001265690.1; NM_001278761.1.
DR STRING; 9823.ENSSSCP00000008471; -.
DR PaxDb; 9823-ENSSSCP00000008471; -.
DR Ensembl; ENSSSCT00000086054.2; ENSSSCP00000070639.1; ENSSSCG00000007933.5.
DR GeneID; 100624981; -.
DR KEGG; ssc:100624981; -.
DR CTD; 100624981; -.
DR eggNOG; KOG1547; Eukaryota.
DR GeneTree; ENSGT00940000158310; -.
DR HOGENOM; CLU_017718_7_1_1; -.
DR OrthoDB; 5396944at2759; -.
DR TreeFam; TF101078; -.
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000007933; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0031105; C:septin complex; IBA:GO_Central.
DR GO; GO:0005940; C:septin ring; IBA:GO_Central.
DR GO; GO:0097227; C:sperm annulus; IEA:Ensembl.
DR GO; GO:0005819; C:spindle; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0061640; P:cytoskeleton-dependent cytokinesis; IBA:GO_Central.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR InterPro; IPR008114; Septin3.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF66; SEPTIN-12; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 1.
DR PRINTS; PR01741; SEPTIN3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212, ECO:0000256|PIRNR:PIRNR006698};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR006698};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 45..316
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 363 AA; 41109 MW; 5B23E9A4001F19ED CRC64;
MDPLRRSSSP CLPQASSPES PPCEMLGYVG IEAVLDQLKI KAMKMGFEFN IMVVGQSGLG
KSTMVNTLFK SKMWKSTLPG LGGPTPQTLQ LHSVTHVIEE NGVKLKLTVT DTPGFGDQIN
NDKCWDPILG YINKQYEQYL QEEILITRQR HIPDTRVHCC VYFVPPTGHC LRPLDIEFLQ
RLCRTVNVVP VIARADSLTI EEREAFRRRI QHNLKTHGIE VYPQKGFDED INDRILNSRI
RDRIPFAVVG ADQEHMVNGR CVLGRKTKWG IIEVENMAHC EFPLLRDLLI RSHLQDLKDI
THNVHYENYR VIRLNESHAL PRGPGWVNLA PAPAPTPTPA SPRTSPGLTK VCRWAQDNSD
EDS
//
