ID F1RLT6_PIG Unreviewed; 355 AA.
AC F1RLT6; A0A4X1V5R9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=G protein subunit alpha z {ECO:0000313|Ensembl:ENSSSCP00000010719.2};
DE SubName: Full=Guanine nucleotide-binding protein G(Z) subunit alpha {ECO:0000313|EMBL:HDB74187.1, ECO:0000313|EMBL:HDB77806.1};
GN Name=GNAZ {ECO:0000313|Ensembl:ENSSSCP00000010719.2,
GN ECO:0000313|VGNC:VGNC:88528};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000010719.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000010719.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000010719.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDB74187.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000010719.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as modulators or transducers in various transmembrane signaling
CC systems. {ECO:0000256|ARBA:ARBA00003069}.
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DR EMBL; DQIR01218710; HDB74187.1; -; Transcribed_RNA.
DR EMBL; DQIR01222329; HDB77806.1; -; Transcribed_RNA.
DR EMBL; DQIR01245965; HDC01443.1; -; Transcribed_RNA.
DR EMBL; DQIR01245966; HDC01444.1; -; Transcribed_RNA.
DR RefSeq; XP_001929116.1; XM_001929081.3.
DR STRING; 9823.ENSSSCP00000010719; -.
DR PaxDb; 9823-ENSSSCP00000010719; -.
DR Ensembl; ENSSSCT00000011007.5; ENSSSCP00000010719.2; ENSSSCG00000010046.5.
DR Ensembl; ENSSSCT00005066503.1; ENSSSCP00005041225.1; ENSSSCG00005041520.1.
DR Ensembl; ENSSSCT00005066512.1; ENSSSCP00005041231.1; ENSSSCG00005041520.1.
DR VGNC; VGNC:88528; GNAZ.
DR eggNOG; KOG0082; Eukaryota.
DR GeneTree; ENSGT00940000160353; -.
DR HOGENOM; CLU_014184_6_0_1; -.
DR OMA; ANSHWFK; -.
DR OrthoDB; 2897309at2759; -.
DR TreeFam; TF300673; -.
DR Reactome; R-SSC-418597; G alpha (z) signalling events.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000010046; Expressed in prefrontal cortex and 35 other cell types or tissues.
DR Genevisible; F1RLT6; SS.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001408; Gprotein_alpha_I.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF65; GUANINE NUCLEOTIDE-BINDING PROTEIN G(Z) SUBUNIT ALPHA; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00441; GPROTEINAI.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 1: Evidence at protein level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1RLT6};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 40751 MW; 74FF23ED0A31DA11 CRC64;
MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV KQMKIIHSGG
FNLEACKEYK PLIIYNAIDS LTRIIRALAA LKIDFHNPDR AYDAVQLFAL TGPAESKGEI
TPELLGVMRR LWADPGAQAC FGRSSEYHLE DNAAYYLNDL ERIAAPDYVP TVEDILRSRD
MTTGIVENKF TFKELTFKMV DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ
TSRMAESLRL FDSICNNNWF VSTSLILFLN KKDLLAQKIR RIPLTVCFPE YGGQNTYEEA
AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK YIGLC
//
