ID F1RZ20_PIG Unreviewed; 1089 AA.
AC F1RZ20;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 5.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=StAR related lipid transfer domain containing 8 {ECO:0000313|Ensembl:ENSSSCP00000013637.5};
GN Name=STARD8 {ECO:0000313|Ensembl:ENSSSCP00000013637.5,
GN ECO:0000313|VGNC:VGNC:93538};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000013637.5, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000013637.5, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000013637.5,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000013637.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1RZ20; -.
DR PaxDb; 9823-ENSSSCP00000013637; -.
DR Ensembl; ENSSSCT00000014022.5; ENSSSCP00000013637.5; ENSSSCG00000012828.5.
DR VGNC; VGNC:93538; STARD8.
DR eggNOG; KOG2200; Eukaryota.
DR GeneTree; ENSGT00950000183061; -.
DR HOGENOM; CLU_029971_0_0_1; -.
DR TreeFam; TF314044; -.
DR Proteomes; UP000008227; Chromosome X.
DR Bgee; ENSSSCG00000012828; Expressed in adult mammalian kidney and 40 other cell types or tissues.
DR ExpressionAtlas; F1RZ20; baseline and differential.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR12659:SF3; STAR-RELATED LIPID TRANSFER PROTEIN 8; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 639..843
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 888..1058
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1089 AA; 120329 MW; AEE21655F406A768 CRC64;
MPPDQQPLFM RLDGSPEPPA GSCVGVSNPK QRTRPPEAEA KKVCGWLRAT GFPQYAQLFE
GSVKKDHSFL DEDSFCRRLM TLNNCASMKL EVHFQCKQNE DSEEEDQCTI SNHWAFQRES
KRWSRVGSSN LLAPPSPGLP VTSSCESVLT ELSATSLPAI TVSLAPEPVD LSLLGRAPSP
SDQPFLSPTR AQEGPKDKTK KHHSRSFLKH LESLRRKEKG GSRQAEPQDS SATPEKATKA
SSFRSRHGFL SAGFYRAKNR AATSASGSGT ETQRAWEAWP VATFQHPQRV HRGDCLVHVP
RDHKPGTFPR SLSIESLCPE DGHCLADWQP GRRWGYEGRR GSCGSTGSHA SIYDNMPELY
PVEPVLAGAE AEEEEGDGDS YTHLDDILQH VWGLQQRVEL WSQAMYPDLG PRDEEEEEAS
SSVEITTSEV EGQTQAPAHE ESLAAGQVDV QPGVLAQAQA QGPAEAELLA QAEAEGPGLA
QDNEQEANSG GEPTSASSLS VEEGHSISDT VASSSELDSS GNSMNEAEAT GSPAGLQASA
PRERRDSGVG ASLTRPCRKL RWHSFQNSHR PSLNSESLEI NRQFASQIHL LHKGSLLRLT
AFMEKYTVPH KQGWVWSMPK FMKRNKTPDY RGQHVFGVPP LIHVQRTGQP LPQSIQQAMR
YLRSQCLDQV GIFRKSGVKS RIQNLRQMNE TSPDNVCYEG QSAYDVADLL KQYFRDLPEP
IFTSKLTTTF LQIYQLLPKD QWLAAAQAAT LLLPDENREV LQTLLYFLSD IASAEENQMT
AGNLAVCLAP SIFHLNVSKK DNHSPRIKSK RSLVGRPGPR DLSENMAATQ GLSHMISDCK
KLFQVPQDMV LQLCSSYSAA ELSPPGPALA ELRQARAAGV SLSLYMEESV QELLRDAAER
FKGWMSVPGP QHTELACKKA PDGHPLRVWK ASTEVAAPPA VVLHRVLRER ALWDEDLLRA
QVLEALMPGV ELYHYVTDSM APHPCRDFVV LRMWRSDLPR GGCLLVSQSL DPEQPVPESG
VRALMLTSQY LMEPCGLGRS RLTHICRADL RGRSPDWYNK VFGHLCAMEV AKIRDSFPTL
QAAGPETKL
//
