ID F1RZ24_PIG Unreviewed; 521 AA.
AC F1RZ24;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Dyskerin pseudouridine synthase 1 {ECO:0000313|Ensembl:ENSSSCP00000013633.3};
GN Name=DKC1 {ECO:0000313|Ensembl:ENSSSCP00000013633.3,
GN ECO:0000313|VGNC:VGNC:87320};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000013633.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000013633.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000013633.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000013633.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC {ECO:0000256|ARBA:ARBA00008999}.
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DR AlphaFoldDB; F1RZ24; -.
DR SMR; F1RZ24; -.
DR STRING; 9823.ENSSSCP00000013633; -.
DR PaxDb; 9823-ENSSSCP00000029318; -.
DR PeptideAtlas; F1RZ24; -.
DR Ensembl; ENSSSCT00000014017.6; ENSSSCP00000013633.3; ENSSSCG00000012823.6.
DR VGNC; VGNC:87320; DKC1.
DR eggNOG; KOG2529; Eukaryota.
DR GeneTree; ENSGT00510000047092; -.
DR HOGENOM; CLU_032087_3_2_1; -.
DR InParanoid; F1RZ24; -.
DR TreeFam; TF300354; -.
DR Reactome; R-SSC-171319; Telomere Extension By Telomerase.
DR Proteomes; UP000008227; Chromosome X.
DR Bgee; ENSSSCG00000012823; Expressed in hindlimb bud and 44 other cell types or tissues.
DR ExpressionAtlas; F1RZ24; baseline and differential.
DR GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR GO; GO:0090661; C:box H/ACA telomerase RNP complex; IEA:Ensembl.
DR GO; GO:0015030; C:Cajal body; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0034513; F:box H/ACA snoRNA binding; IEA:Ensembl.
DR GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR GO; GO:0003720; F:telomerase activity; IEA:Ensembl.
DR GO; GO:0070034; F:telomerase RNA binding; IEA:Ensembl.
DR GO; GO:0000495; P:box H/ACA RNA 3'-end processing; IBA:GO_Central.
DR GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:Ensembl.
DR GO; GO:1990481; P:mRNA pseudouridine synthesis; IBA:GO_Central.
DR GO; GO:1904851; P:positive regulation of establishment of protein localization to telomere; IEA:Ensembl.
DR GO; GO:1904874; P:positive regulation of telomerase RNA localization to Cajal body; IEA:Ensembl.
DR GO; GO:0032212; P:positive regulation of telomere maintenance via telomerase; IEA:Ensembl.
DR GO; GO:0031118; P:rRNA pseudouridine synthesis; IBA:GO_Central.
DR GO; GO:0090666; P:scaRNA localization to Cajal body; IEA:Ensembl.
DR GO; GO:0031120; P:snRNA pseudouridine synthesis; IBA:GO_Central.
DR GO; GO:0090669; P:telomerase RNA stabilization; IEA:Ensembl.
DR GO; GO:0007004; P:telomere maintenance via telomerase; IEA:Ensembl.
DR CDD; cd02572; PseudoU_synth_hDyskerin; 1.
DR CDD; cd21148; PUA_Cbf5; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR Gene3D; 2.30.130.10; PUA domain; 1.
DR InterPro; IPR012960; Dyskerin-like.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR002501; PsdUridine_synth_N.
DR InterPro; IPR002478; PUA.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR004802; tRNA_PsdUridine_synth_B_fam.
DR InterPro; IPR032819; TruB_C.
DR InterPro; IPR004521; Uncharacterised_CHP00451.
DR NCBIfam; TIGR00425; CBF5; 1.
DR NCBIfam; TIGR00451; unchar_dom_2; 1.
DR PANTHER; PTHR23127; CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5; 1.
DR PANTHER; PTHR23127:SF0; H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1; 1.
DR Pfam; PF08068; DKCLD; 1.
DR Pfam; PF01472; PUA; 1.
DR Pfam; PF16198; TruB_C_2; 1.
DR Pfam; PF01509; TruB_N; 1.
DR SMART; SM01136; DKCLD; 1.
DR SMART; SM00359; PUA; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR PROSITE; PS50890; PUA; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1RZ24};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 49..107
FT /note="Dyskerin-like"
FT /evidence="ECO:0000259|SMART:SM01136"
FT DOMAIN 298..372
FT /note="PUA"
FT /evidence="ECO:0000259|SMART:SM00359"
FT REGION 435..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 521 AA; 58153 MW; 155A5B00E8639815 CRC64;
LACFVEVLIL PKKHKKKKER KSLPEEDVAE IQHAEEFLIK PESKVAQLDT SQWPLLLKNF
DKLNVRTTHY TPLPCGSNPL KREIGDYIRT GFINLDKPSN PSSHEVVAWI RRILRVEKTG
HSGTLDPKVT GCLIVCIERA TRLVKSQQSA GKEYVGIVRL HNAIEGGTQL SRALETLTGA
LFQRPPLIAA VKRQLRVRTV YESKMIEFDP ERRLGIFWVS CEAGTYIRTL CVHLGLLLGV
GGQMQELRRV RSGVMSEKDH MVTMHDVLDA QWLYDNHKDE SYLRRVVYPL EKLLTSHKRL
VMKDSAVNAI CYGAKIMLPG VLRYEDGIEV NQEIVVITTK GEAICMAVAL MTTAVISTCD
HGVVAKIKRV IMERDTYPRK WGLGPKASQK RLMIKQGLLD KHGKPTDSTP AAWTQDYVDY
SDPAKKEAAA KAVKAPPAVA EAAKAPQLVA EAAKTPKRKR ESESDETSPA AAQLPKKEKK
KKKDKKPKAA PEGAAEPGDG DSDTTKKKKK KKKIKVEVVS E
//
