ID F1S1I3_PIG Unreviewed; 502 AA.
AC F1S1I3; A0A4X1TC90;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Potassium voltage-gated channel subfamily V member 1 {ECO:0000256|ARBA:ARBA00020321};
DE AltName: Full=Voltage-gated potassium channel subunit Kv8.1 {ECO:0000256|ARBA:ARBA00032563};
GN Name=KCNV1 {ECO:0000313|Ensembl:ENSSSCP00000006432.2,
GN ECO:0000313|VGNC:VGNC:89390};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000006432.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000006432.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000006432.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDB60668.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000006432.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potassium channel subunit that does not form functional
CC channels by itself. Modulates KCNB1 and KCNB2 channel activity by
CC shifting the threshold for inactivation to more negative values and by
CC slowing the rate of inactivation. Can down-regulate the channel
CC activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in
CC intracellular membranes. {ECO:0000256|ARBA:ARBA00024762}.
CC -!- SUBUNIT: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and
CC KCND1. {ECO:0000256|ARBA:ARBA00025980}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. V (TC 1.A.1.2)
CC subfamily. Kv8.1/KCNV1 sub-subfamily. {ECO:0000256|ARBA:ARBA00009030}.
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DR EMBL; DQIR01205191; HDB60668.1; -; Transcribed_RNA.
DR RefSeq; XP_001924676.2; XM_001924641.4.
DR RefSeq; XP_013851993.1; XM_013996539.1.
DR RefSeq; XP_013851994.1; XM_013996540.1.
DR RefSeq; XP_013851995.1; XM_013996541.1.
DR STRING; 9823.ENSSSCP00000006432; -.
DR PaxDb; 9823-ENSSSCP00000006432; -.
DR Ensembl; ENSSSCT00000006608.5; ENSSSCP00000006432.2; ENSSSCG00000006021.5.
DR Ensembl; ENSSSCT00005026285.1; ENSSSCP00005015954.1; ENSSSCG00005016714.1.
DR GeneID; 100155464; -.
DR KEGG; ssc:100155464; -.
DR CTD; 27012; -.
DR VGNC; VGNC:89390; KCNV1.
DR eggNOG; KOG3713; Eukaryota.
DR GeneTree; ENSGT00940000159740; -.
DR HOGENOM; CLU_011722_4_1_1; -.
DR OMA; AWFTAEF; -.
DR OrthoDB; 1478695at2759; -.
DR TreeFam; TF313103; -.
DR Reactome; R-SSC-1296072; Voltage gated Potassium channels.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000006021; Expressed in occipital cortex and 10 other cell types or tissues.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18424; BTB_POZ_KCNV1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003970; K_chnl_volt-dep_Kv8.1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF38; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY V MEMBER 1; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01493; KV8CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 213..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..159
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 170..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 56450 MW; 701BF44835FE4634 CRC64;
MELPPSSRAL LDSPLDSASL TSLDSSVFCS EGEGEPLALG DSFTVNVGGS RFVLSQQALS
CFPHTRLGKL AVVVASCRRP GALAAVPSPL ELCDDANPVD NEYFFDRSSQ AFRYVLHYYR
TGRLHVMEQL CALSFLQEIQ YWGIDELSID SCCRDRYFRR KELSETLDFK KDTEDQESQH
ESEQDFSQGP CPTVRQKLWN ILEKPGSSTA ARIFGVISII FVAVSIVNMA LMSAELSWLD
LQLLEILEYV CISWFTGEFV LRFLCVRDRC RFLRKVPNII DLLAILPFYI TLLVESLSGS
QTTQELENVG RIVQVLRLLR ALRMLKLGRH STGLRSLGMT ITQCYEEVGL LLLFLSVGIS
IFSTVEYFAE QSIPDTTFTS VPCAWWWATT SMTTVGYGDI RPDTTTGKIV AFVCILSGIL
VLALPIAIIN DRFSACYFTL KLKEAAVRQR EALKKLTKNI ATDSYISVNL RDVYARSIME
MLRLKGRERA STRSSGGDDF WF
//
