ID F1S2H7_PIG Unreviewed; 1481 AA.
AC F1S2H7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 5.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=IQ motif containing GTPase activating protein 2 {ECO:0000313|Ensembl:ENSSSCP00000014980.5};
GN Name=IQGAP2 {ECO:0000313|Ensembl:ENSSSCP00000014980.5,
GN ECO:0000313|VGNC:VGNC:89192};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000014980.5, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000014980.5, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000014980.5,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000014980.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR PaxDb; 9823-ENSSSCP00000014980; -.
DR PeptideAtlas; F1S2H7; -.
DR Ensembl; ENSSSCT00000015389.5; ENSSSCP00000014980.5; ENSSSCG00000014088.5.
DR VGNC; VGNC:89192; IQGAP2.
DR eggNOG; KOG2128; Eukaryota.
DR GeneTree; ENSGT00950000183076; -.
DR HOGENOM; CLU_340382_0_0_1; -.
DR TreeFam; TF313078; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Bgee; ENSSSCG00000014088; Expressed in ovary and 43 other cell types or tissues.
DR ExpressionAtlas; F1S2H7; baseline and differential.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR CDD; cd21275; CH_IQGAP2; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF12; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1S2H7};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 41..156
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 594..627
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 860..1093
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 165..192
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1354..1381
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1481 AA; 169906 MW; 376561C857299F32 CRC64;
MPHEEQASLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW MEVCLVEELP
PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY KKSGLHFRHT DNTVQWLRAM
ESIGLPKIFY PETTDVYDRK NIPRMIYCIH ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS
NMRKELEKYG IQMPSFSKIG GILANELSVD EAALHAAVIA INEAIEKGIA EQTIVTLRNP
NAVLTSVDDS LAQEYQKELW EAKKRKEENA RLKNNCISEE ERDAYEELLT QAEIQGHINK
VNRLAAVDHI NTVLREGDPE NTLLALQKPE AQLPTVYPFA APMYQNELFN LQKQNAMNYL
PHEELVIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPTMG FNNLDEMHVE RYANALLSIK
LEALSQGQEN LSWNEIQNCI DMVNTEIQEE NDRVVAVGYI NEAIDEGDAL KTLDSLLLPT
AKIKDIDPDS AQHYQDVLYH AKSQKFLDPH SASKILWLDE IQHAVNEANK DKDKAKQWVT
LVVDVNQFLE KEKQSDILSV LKSAVPNTND IIPECADRYY DALVKAKDQK SNGVSAEGSW
LKLTLQDKYD YYYNIDSQES SWVPPESFLP KESWLTGKEI KAFWKGHQQR ASYMKRRQMF
IDNISAIVKI QSWFRMRRAR KNYLSRLQYF KDHNNEIVKI QSLLRANKAR DDYKTLVGSE
NPPLTVIRKF VHLLDQSDLD FQEELEVARL REEVVTKIRG NQQLEKDLNL MDIKIGLLVK
NRITLEDVIS HRTKLNKKKG GEMEILNSTD NQGIKSLSKE RRKTLETYQQ LFYLLQTNPL
YLAKLIFQMP QNKSTKFMDT VIFTLYNYAS NQREEYLLLK LFKTALEEEI KSKVDQVQDI
VTGNPTVIKM VVSFNRGARG QNTLRQLLAP VVKEIIDDKS LMINTSPVEV YKAWVNQLET
QTGEASNLPY DVTTEQALTY PEVKNKLEAS IENLRRVTDK VLNSIISSLD LLPYGLRYIA
KVLKNSIHEK FPDATEDELL KIVGNLLYYR YMNPAIVAPD GFDIIDMTAG GQINSDQRRN
LGSVAKVLQH AASNKLFEGE NEHLASMNNY LSETYQEFRK YFKEACNVPE PEEKFNMDKY
TDVVTVSKPV IYISIEEIIS THSLLLEHQD AIAPEKTDLL NELLELLGEV PNVESFLGEG
AVDPNDPDRV NTLNQLSKTE ISLSLTSKYD IGDGEAIDGQ SLMIKTKKLI IDVIRNQPGS
TLTEILETPA TTKQEADHAA DMVSRAILDS RTPEDLKHSQ SVVEDAQLPL EQKKRKIQRN
LRTLEQTGHV SSKNKYQDIL NAMAKDIRNQ RIHRKLRKAE LAKLQQTLNA LNKKAAFFEE
QINYYDTYIK TCLDNLKRKN SRRSIKLDGK GEPKGARRAK PVRYTAAKLH EKGVLLDIDD
LQTNQFKNVT FDISSTEDVG ILMSDRNSWV LIWKRCSSIF R
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