ID F1SM20_PIG Unreviewed; 533 AA.
AC F1SM20; M1VEG8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN Name=UGT1A6 {ECO:0000313|Ensembl:ENSSSCP00000017281.2};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000017281.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000017281.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000017281.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAM95320.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:BAM95320.1};
RX PubMed=23449330; DOI=10.1248/bpb.b12-00986;
RA Miyake Y., Mayumi K., Jinno H., Tanaka-Kagawa T., Narimatsu S., Hanioka N.;
RT "cDNA Cloning and Functional Analysis of Minipig Uridine Diphosphate-
RT Glucuronosyltransferase 1A1.";
RL Biol. Pharm. Bull. 36:452-461(2013).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000017281.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|RuleBase:RU362059};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167, ECO:0000256|RuleBase:RU362059}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167,
CC ECO:0000256|RuleBase:RU362059}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR EMBL; AB704409; BAM95320.1; -; mRNA.
DR RefSeq; NP_001265679.1; NM_001278750.1.
DR PaxDb; 9823-ENSSSCP00000017281; -.
DR Ensembl; ENSSSCT00000017762.3; ENSSSCP00000017281.2; ENSSSCG00000036274.3.
DR GeneID; 100152603; -.
DR KEGG; ssc:100152603; -.
DR CTD; 54578; -.
DR eggNOG; KOG1192; Eukaryota.
DR GeneTree; ENSGT00940000162976; -.
DR HOGENOM; CLU_012949_5_0_1; -.
DR OrthoDB; 382054at2759; -.
DR TreeFam; TF315472; -.
DR Proteomes; UP000008227; Chromosome 15.
DR Bgee; ENSSSCG00000036274; Expressed in duodenum and 32 other cell types or tissues.
DR Genevisible; M1VEG8; SS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF157; UDP GLUCURONOSYLTRANSFERASE 1 FAMILY POLYPEPTIDE A3 PRECURSOR-RELATED; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003718};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362059};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SM20};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|RuleBase:RU362059};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362059};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362059}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT CHAIN 28..533
FT /note="UDP-glucuronosyltransferase"
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT /id="PRO_5014485477"
FT TRANSMEM 491..514
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362059"
SQ SEQUENCE 533 AA; 59053 MW; 9E105C0AC684509D CRC64;
MTAGSRGLRP LILGLLLCAL GPTVSWGGKL LVIPVEGSHW LSMVGVIQQL QQKGHDTVVV
APDATMYIKE GAFYTLKTYP VPFRKEDLRE AFVSLGHTIF ENDPFLQRML KIYKKVKKDS
ALLLSACSHL LHNKELMASL AASGFDAVFT DPFLPCGPIV AQYLGLPAVF FLNGLPCQLD
FQGTQCPNPL SYVPRPLSGN SDHMTFLERV KNMLVALSEG FLCSAVYSPY APLASEVLQR
DVTVQDLMSS ASVWLIRNDF VNNYPRPIMP NTVFIGGINC ASKTPLSQEF EAYVNASGEH
GIVVFSLGSM VSEIPEQKAM EIADALGKIP QTVLWRYTGP APPNLAKNTK LVKWLPQNDL
LGHPKARAFI THSGSHGIYE GICNGVPMVM MPLFGDQMDN AKRMETRGAG VTLNVLEMTS
KDLENALNTV IKDKSYKENI MRLSSLHKDR PIEPLDLAVF WVEFVMRHKG APHLRPAAHD
LTWYQYHSLD VIGFLLAVGL TVVFIAFKCC VFAYRKCFGK KGRVKKSHKS KTH
//
