ID F1SU66_PIG Unreviewed; 430 AA.
AC F1SU66; A0A4X1VX14;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Small ribosomal subunit protein uS5m {ECO:0000256|ARBA:ARBA00039335};
DE AltName: Full=28S ribosomal protein S5, mitochondrial {ECO:0000256|ARBA:ARBA00041606};
GN Name=MRPS5 {ECO:0000313|Ensembl:ENSSSCP00000008663.2,
GN ECO:0000313|VGNC:VGNC:90398};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000008663.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000008663.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000008663.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PDB:5AJ3, ECO:0007829|PDB:5AJ4}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS).
RX PubMed=25837512; DOI=10.1126/science.aaa3872;
RA Greber B.J., Bieri P., Leibundgut M., Leitner A., Aebersold R.,
RA Boehringer D., Ban N.;
RT "Ribosome. The complete structure of the 55S mammalian mitochondrial
RT ribosome.";
RL Science 348:303-308(2015).
RN [3] {ECO:0007829|PDB:6GAW, ECO:0007829|PDB:6GAZ}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS).
RX PubMed=30089917; DOI=10.1038/s41586-018-0373-y;
RA Kummer E., Leibundgut M., Rackham O., Lee R.G., Boehringer D.,
RA Filipovska A., Ban N.;
RT "Unique features of mammalian mitochondrial translation initiation revealed
RT by cryo-EM.";
RL Nature 560:263-267(2018).
RN [4] {ECO:0000313|EMBL:HDA49884.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [5] {ECO:0007829|PDB:6YDP, ECO:0007829|PDB:6YDW}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS).
RX PubMed=32602580; DOI=10.15252/embj.2020104820;
RA Kummer E., Ban N.;
RT "Structural insights into mammalian mitochondrial translation elongation
RT catalyzed by mtEFG1.";
RL EMBO J. 39:e104820-e104820(2020).
RN [6] {ECO:0007829|PDB:7NQH, ECO:0007829|PDB:7NQL}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS).
RX PubMed=33878294; DOI=10.1016/j.molcel.2021.03.042;
RA Kummer E., Schubert K.N., Schoenhut T., Scaiola A., Ban N.;
RT "Structural basis of translation termination, rescue, and recycling in
RT mammalian mitochondria.";
RL Mol. Cell 81:2566-2582(2021).
RN [7] {ECO:0007829|PDB:8OIN, ECO:0007829|PDB:8OIP}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS).
RX PubMed=37141370; DOI=10.1126/science.adf9890;
RA Saurer M., Leibundgut M., Nadimpalli H.P., Scaiola A., Schonhut T.,
RA Lee R.G., Siira S.J., Rackham O., Dreos R., Lenarcic T., Kummer E.,
RA Gatfield D., Filipovska A., Ban N.;
RT "Molecular basis of translation termination at noncanonical stop codons in
RT human mitochondria.";
RL Science 380:531-536(2023).
RN [8] {ECO:0000313|Ensembl:ENSSSCP00000008663.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS5 family.
CC {ECO:0000256|ARBA:ARBA00008945, ECO:0000256|RuleBase:RU003823}.
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DR EMBL; DQIR01094408; HDA49884.1; -; Transcribed_RNA.
DR RefSeq; XP_003124867.3; XM_003124819.5.
DR PDB; 5AJ3; EM; 3.60 A; E=1-430.
DR PDB; 5AJ4; EM; 3.80 A; AE=88-430.
DR PDB; 6GAW; EM; 3.20 A; AE=1-430.
DR PDB; 6GAZ; EM; 3.10 A; AE=1-430.
DR PDB; 6YDP; EM; 3.00 A; AE=1-430.
DR PDB; 6YDW; EM; 4.20 A; AE=1-430.
DR PDB; 7NQH; EM; 3.50 A; AE=1-430.
DR PDB; 7NQL; EM; 3.40 A; AE=1-430.
DR PDB; 7NSI; EM; 4.60 A; AE=1-430.
DR PDB; 7NSJ; EM; 3.90 A; AE=1-430.
DR PDB; 8OIN; EM; 3.60 A; Ad=1-430.
DR PDB; 8OIP; EM; 3.60 A; Ad=1-430.
DR PDBsum; 5AJ3; -.
DR PDBsum; 5AJ4; -.
DR PDBsum; 6GAW; -.
DR PDBsum; 6GAZ; -.
DR EMDB; EMD-12568; -.
DR EMDB; EMD-16894; -.
DR EMDB; EMD-16895; -.
DR EMDB; EMD-4369; -.
DR PaxDb; 9823-ENSSSCP00000008663; -.
DR Ensembl; ENSSSCT00000008889.5; ENSSSCP00000008663.2; ENSSSCG00000008113.5.
DR Ensembl; ENSSSCT00005000396.1; ENSSSCP00005000162.1; ENSSSCG00005000271.1.
DR GeneID; 100521262; -.
DR KEGG; ssc:100521262; -.
DR CTD; 64969; -.
DR VGNC; VGNC:90398; MRPS5.
DR eggNOG; KOG2646; Eukaryota.
DR GeneTree; ENSGT00390000001878; -.
DR HOGENOM; CLU_050434_0_0_1; -.
DR OMA; LICHRAI; -.
DR OrthoDB; 5479674at2759; -.
DR TreeFam; TF313823; -.
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000008113; Expressed in heart left ventricle and 45 other cell types or tissues.
DR Genevisible; F1SU66; SS.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:UniProtKB-UniRule.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR000851; Ribosomal_uS5.
DR InterPro; IPR005324; Ribosomal_uS5_C.
DR InterPro; IPR013810; Ribosomal_uS5_N.
DR InterPro; IPR018192; Ribosomal_uS5_N_CS.
DR InterPro; IPR048584; Ribosomal_uS5m_N.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR48277; MITOCHONDRIAL RIBOSOMAL PROTEIN S5; 1.
DR PANTHER; PTHR48277:SF1; MITOCHONDRIAL RIBOSOMAL PROTEIN S5; 1.
DR Pfam; PF00333; Ribosomal_S5; 1.
DR Pfam; PF03719; Ribosomal_S5_C; 1.
DR Pfam; PF21251; S5p_N; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00585; RIBOSOMAL_S5; 1.
DR PROSITE; PS50881; S5_DSRBD; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:5AJ3, ECO:0007829|PDB:5AJ4};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274, ECO:0000256|PROSITE-
KW ProRule:PRU00268};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980, ECO:0000256|PROSITE-
KW ProRule:PRU00268}.
FT DOMAIN 218..282
FT /note="S5 DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50881"
FT REGION 106..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 48130 MW; 905E7CCDBCBA7EEE CRC64;
MAAAVRAAGF FPGLFGASAG NLWSRQLYLN TFPAASILTS KTFPSNGPLS PPGTRDNHHF
TSLACALQTQ CSISSPSNWM GQQYRSYSFF TKLTADELWK GALAESGAGA RKGRGKRTKK
KRRKDLNRGQ IIGEGRHGFL WPGLNIPLMR NGAVQTIAQR SKEDQEKVEA DMVQQREEWD
RRRKMKVKRE RGWSGNTWGG VSLGPPDPGP NGETYDDFDT RILEVRNVFN MTAKEGRKRS
VRVLVAVGNG KGAAGFAIGK ATERADAFRK AKNRAVHYLH YIERYEDHTI YHDISLKFKR
THIKMKKQPR GYGLHCHRAI MTICRLIGIK DLYAKVSGSV NMLNLTRGLF LGLSRQETHQ
QLADKKSLHV VEFREECGPL PIVVASPQGA LRKDPEPEDE VPDITLDWED VKAAQGMKRS
VWSGLKRAAT
//
