ID F1Z4S1_9SPHN Unreviewed; 505 AA.
AC F1Z4S1;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Tryptophan halogenase, putative {ECO:0000313|EMBL:EGD60392.1};
GN ORFNames=Y88_0040 {ECO:0000313|EMBL:EGD60392.1};
OS Novosphingobium nitrogenifigens DSM 19370.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=983920 {ECO:0000313|EMBL:EGD60392.1, ECO:0000313|Proteomes:UP000004728};
RN [1] {ECO:0000313|EMBL:EGD60392.1, ECO:0000313|Proteomes:UP000004728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19370 {ECO:0000313|EMBL:EGD60392.1,
RC ECO:0000313|Proteomes:UP000004728};
RX PubMed=22156397; DOI=10.1128/JB.06381-11;
RA Strabala T.J., Macdonald L., Liu V., Smit A.M.;
RT "Draft Genome Sequence of Novosphingobium nitrogenifigens Y88T.";
RL J. Bacteriol. 194:201-201(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGD60392.1}.
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DR EMBL; AEWJ01000022; EGD60392.1; -; Genomic_DNA.
DR AlphaFoldDB; F1Z4S1; -.
DR STRING; 983920.Y88_0040; -.
DR eggNOG; COG0665; Bacteria.
DR HOGENOM; CLU_022247_0_0_5; -.
DR InParanoid; F1Z4S1; -.
DR Proteomes; UP000004728; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000004728}.
FT ACT_SITE 72
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 3..6
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 72
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 179
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 348
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 352
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 505 AA; 55400 MW; 95015D117EE266B2 CRC64;
MGGGTAGWLA AGLLAARLGL AARDDLQITV VESPRVPILG VGEGTWPTFR QSLKAMGIGE
ADFLAACDAT FKQGSQFVGW NQSPVPGGHS YIHPFTPPHR FGELDLASAW LAEPTTGFDE
AVCFQTVLCR AGLAPKLRNS PDYEGIGNYA YHFDAGKVAA FLKDHCIAHL GVKHVADDVL
DCVTDRGDDG EGDGAITALR TARHGDLPGD LFIDCSGQHG VLMDRVYKAR MVDCRDILLV
DTALAIPVPY PQADSPIASV TLATAQSAGW IWDIGLKTRR GTGYVYSSRH VSHDEARHTL
DRYVRTISGK PMQDEPRRIA INSGYRERFW IANCVAIGVS AGFIEPLEAS SIAMIEISAN
HLAEHLTFDR KVMAIEAGRF NRKMDQLWHD VIDFLKLHYV LSDRTEPFWL DNRAPCSIPS
SLRDNLRIWQ NRPPIEGDFV HTCQLFGPAS YQYILYGMHR AGAVKGDASC KPRNERANNH
IGEVRALTAK LSRVLGPNRD FAVGI
//
