ID F2BND8_STRSA Unreviewed; 354 AA.
AC F2BND8;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase {ECO:0000313|EMBL:EGF10086.1};
DE EC=2.7.1.148 {ECO:0000313|EMBL:EGF10086.1};
GN Name=ispE {ECO:0000313|EMBL:EGF10086.1};
GN ORFNames=HMPREF9394_0076 {ECO:0000313|EMBL:EGF10086.1};
OS Streptococcus sanguinis SK1057.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888821 {ECO:0000313|EMBL:EGF10086.1, ECO:0000313|Proteomes:UP000005977};
RN [1] {ECO:0000313|EMBL:EGF10086.1, ECO:0000313|Proteomes:UP000005977}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK1057 {ECO:0000313|EMBL:EGF10086.1,
RC ECO:0000313|Proteomes:UP000005977};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GSP E family.
CC {ECO:0000256|ARBA:ARBA00006611}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGF10086.1}.
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DR EMBL; AFBA01000001; EGF10086.1; -; Genomic_DNA.
DR RefSeq; WP_002899359.1; NZ_GL878514.1.
DR AlphaFoldDB; F2BND8; -.
DR GeneID; 61537123; -.
DR PATRIC; fig|888821.3.peg.73; -.
DR eggNOG; COG2805; Bacteria.
DR HOGENOM; CLU_013446_4_0_9; -.
DR Proteomes; UP000005977; Unassembled WGS sequence.
DR GO; GO:0050515; F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01131; PilT; 1.
DR Gene3D; 3.30.450.90; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006321; PilT/PilU.
DR InterPro; IPR001482; T2SS/T4SS_dom.
DR NCBIfam; TIGR01420; pilT_fam; 1.
DR PANTHER; PTHR30486:SF13; TWITCHING MOBILITY PROTEIN; 1.
DR PANTHER; PTHR30486; TWITCHING MOTILITY PROTEIN PILT; 1.
DR Pfam; PF00437; T2SSE; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00662; T2SP_E; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:EGF10086.1};
KW Transferase {ECO:0000313|EMBL:EGF10086.1}.
FT DOMAIN 193..207
FT /note="Bacterial type II secretion system protein E"
FT /evidence="ECO:0000259|PROSITE:PS00662"
SQ SEQUENCE 354 AA; 39285 MW; EFCEDD5D6D77129C CRC64;
MNLDELIKQA IEAGASDIHF TVGAEPTMRL HGRLTQLNNT ILTNEDTVRF TKHILNEKQI
AHLLEVGEVD CAYEVDNGYR LRVNIFKQKN NCGIALRVIP KDIPSMESLG LPPVIKKLAE
KRRGLILVTG PTGSGKSTTL ATMINYMNSL RDEHIITIED PIEYMHTHNK CLVNQRELGA
DTQSFGNALR GALRQDPDVI LVGEMRDKET IEIALRAAET GHLVLSTLHT VGAVNTMDRI
IDVFPAEQQE QIRVQLSAVM EGVVSQQLMR TATGKGRVAA FEIMLGTPAI RNLIREGKTH
QLLTPIQTGA QLGMITMDTS LMGLYRRNVI DQRTLLSYSV DRAQVEKSLG IVGY
//
