ID F2IEM4_FLUTR Unreviewed; 310 AA.
AC F2IEM4;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Glyoxylate reductase {ECO:0000313|EMBL:AEA44563.1};
DE EC=1.1.1.215 {ECO:0000313|EMBL:AEA44563.1};
DE EC=1.1.1.26 {ECO:0000313|EMBL:AEA44563.1};
GN OrderedLocusNames=Fluta_2579 {ECO:0000313|EMBL:AEA44563.1};
OS Fluviicola taffensis (strain DSM 16823 / NCIMB 13979 / RW262).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Crocinitomicaceae; Fluviicola.
OX NCBI_TaxID=755732 {ECO:0000313|EMBL:AEA44563.1, ECO:0000313|Proteomes:UP000007463};
RN [1] {ECO:0000313|EMBL:AEA44563.1, ECO:0000313|Proteomes:UP000007463}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16823 / RW262 / RW262 {ECO:0000313|Proteomes:UP000007463};
RX PubMed=22180807; DOI=10.4056/sigs.2124912;
RA Woyke T., Chertkov O., Lapidus A., Nolan M., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA Pagani I., Ivanova N., Huntemann M., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M., Rohde M.,
RA Mwirichia R., Sikorski J., Tindall B.J., Goker M., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of the gliding freshwater bacterium Fluviicola
RT taffensis type strain (RW262).";
RL Stand. Genomic Sci. 5:21-29(2011).
RN [2] {ECO:0000313|Proteomes:UP000007463}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16823 / RW262 / RW262 {ECO:0000313|Proteomes:UP000007463};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Pagani I.,
RA Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B.,
RA Pomrenke H.G., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Fluviicola taffensis DSM 16823.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP002542; AEA44563.1; -; Genomic_DNA.
DR AlphaFoldDB; F2IEM4; -.
DR STRING; 755732.Fluta_2579; -.
DR KEGG; fte:Fluta_2579; -.
DR eggNOG; COG1052; Bacteria.
DR HOGENOM; CLU_019796_1_2_10; -.
DR Proteomes; UP000007463; Chromosome.
DR GO; GO:0008873; F:gluconate 2-dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0047964; F:glyoxylate reductase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR10996:SF257; GLYCERATE DEHYDROGENASE HPR, PEROXISOMAL; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719,
KW ECO:0000313|EMBL:AEA44563.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007463}.
FT DOMAIN 5..308
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 101..278
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 310 AA; 34190 MW; 3E4EDD9BB18DA936 CRC64;
MDFGMERLHK AGIDVTVWEE DRNLTPEELV AHCQKVDGLL NVGMNQLNRE LMAACPNLKV
ISLHSVGYDH VDLEAAKELG IKVGNTPGVL TNATADTAFL LIQSVARNAF YLNHQILEDN
WKASQEIENF GIELRGKTLG IFGLGSIGFA LAKRCKAVFD MEIIYHNRGN NEEAEKLLGA
RRVELEELLA ESDVISIHAN LTTENTGIFN DEVFQQMKQS AIFINTARGG FHNELDLILA
LQKKHIWGAG LDVTNPEPMH ADNPLLTMPH VCVLPHIGSA TLETRTAMLD LAIDNLIAGL
NGKPLKTELI
//
