ID F2IWE7_POLGS Unreviewed; 606 AA.
AC F2IWE7;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Putative transporter, NiCoT family {ECO:0000313|EMBL:ADZ69246.1};
GN OrderedLocusNames=SL003B_0816 {ECO:0000313|EMBL:ADZ69246.1};
OS Polymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Polymorphum.
OX NCBI_TaxID=991905 {ECO:0000313|EMBL:ADZ69246.1, ECO:0000313|Proteomes:UP000008130};
RN [1] {ECO:0000313|EMBL:ADZ69246.1, ECO:0000313|Proteomes:UP000008130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 25793 / CGMCC 1.9160 / SL003B-26A1
RC {ECO:0000313|Proteomes:UP000008130};
RX PubMed=21478361; DOI=10.1128/JB.00333-11;
RA Li S.G., Tang Y.Q., Nie Y., Cai M., Wu X.L.;
RT "Complete genome sequence of Polymorphum gilvum SL003B-26A1T, a crude oil-
RT degrading bacterium from oil-polluted saline soil.";
RL J. Bacteriol. 193:2894-2895(2011).
CC -!- FUNCTION: Efflux system for nickel and cobalt.
CC {ECO:0000256|ARBA:ARBA00002510}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP002568; ADZ69246.1; -; Genomic_DNA.
DR RefSeq; WP_013651563.1; NC_015259.1.
DR AlphaFoldDB; F2IWE7; -.
DR STRING; 991905.SL003B_0816; -.
DR KEGG; pgv:SL003B_0816; -.
DR PATRIC; fig|991905.3.peg.828; -.
DR eggNOG; COG2215; Bacteria.
DR eggNOG; COG3683; Bacteria.
DR HOGENOM; CLU_444709_0_0_5; -.
DR Proteomes; UP000008130; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0015099; F:nickel cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006824; P:cobalt ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR010412; DUF1007.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR PANTHER; PTHR40659; NICKEL/COBALT EFFLUX SYSTEM RCNA; 1.
DR PANTHER; PTHR40659:SF1; NICKEL_COBALT EFFLUX SYSTEM RCNA; 1.
DR Pfam; PF06226; DUF1007; 1.
DR Pfam; PF03824; NicO; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Cobalt transport {ECO:0000256|ARBA:ARBA00022426};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nickel {ECO:0000256|ARBA:ARBA00022596};
KW Nickel transport {ECO:0000256|ARBA:ARBA00023112};
KW Reference proteome {ECO:0000313|Proteomes:UP000008130};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..606
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003283639"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..91
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 444..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..460
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 63958 MW; AD34329694AC795C CRC64;
MNSLRRTLVR GLVAAALLCV PLVPAGAHPH VFVEARTQLV FDDSGGAVAV HQVFRFDDAY
TAFAIQGFDT DGDGIFSSEE LADLAKVNVD SMEEYGYFTF GDNARVELDF RKPETYWLEV
VEVALQDYWA MKPEDIAAIR EDAARSGETA MQSVQLLELH FTLPLKEPTD ASRPITLDVY
DPTYYVDFRF ARGEEALGLR NAPDAGCSIE RREPPELDSA TAAALASIGP DQRDLPPELQ
DAAASQVNQM IVTCAGMPGV AAQPAEMPAA AVDMPALEGG VRLRTLAGAD DGAATAPGAS
VGMADRLFGT VARLQSEFYQ KLVAALRAFR SNSDAAWLLA GLSFAYGIFH AAGPGHGKAI
IASYVLASGD TLKKGVALSF VSAFAQALTA ILLVGAAAVV FRLTSIAIQD TARWLEIGSY
ALVTALGAWL LWVKALRPML AGATTGGHHH HHHHDHAHDQ DRHHHGHGDP SHDHDHAPDG
VCSSCGHIHA PTPEMLKEEL TVGRAASIVL AIGLRPCSGA LIVLVFALSQ GMIVAGIGST
LAMALGTGIT VAALATLAVG AKGAAVRFFG GDSVWAVRLH RAIEIVAAAV VFLLGATLLI
ATLGWG
//
