ID   F2JZJ5_MARM1            Unreviewed;       530 AA.
AC   F2JZJ5;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=cyclic-guanylate-specific phosphodiesterase {ECO:0000256|ARBA:ARBA00012282};
DE            EC=3.1.4.52 {ECO:0000256|ARBA:ARBA00012282};
GN   OrderedLocusNames=Marme_0482 {ECO:0000313|EMBL:ADZ89778.1};
OS   Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 /
OS   MMB-1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Oceanospirillaceae; Marinomonas.
OX   NCBI_TaxID=717774 {ECO:0000313|EMBL:ADZ89778.1, ECO:0000313|Proteomes:UP000001062};
RN   [1] {ECO:0000313|EMBL:ADZ89778.1, ECO:0000313|Proteomes:UP000001062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1
RC   {ECO:0000313|Proteomes:UP000001062};
RX   PubMed=22675599; DOI=10.4056/sigs.2545743;
RA   Lucas-Elio P., Goodwin L., Woyke T., Pitluck S., Nolan M., Kyrpides N.C.,
RA   Detter J.C., Copeland A., Teshima H., Bruce D., Detter C., Tapia R.,
RA   Han S., Land M.L., Ivanova N., Mikhailova N., Johnston A.W.,
RA   Sanchez-Amat A.;
RT   "Complete genome sequence of the melanogenic marine bacterium Marinomonas
RT   mediterranea type strain (MMB-1(T)).";
RL   Stand. Genomic Sci. 6:63-73(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine +
CC         H(+); Xref=Rhea:RHEA:24902, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58754, ChEBI:CHEBI:58805; EC=3.1.4.52;
CC         Evidence={ECO:0000256|ARBA:ARBA00034290};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP002583; ADZ89778.1; -; Genomic_DNA.
DR   RefSeq; WP_013659684.1; NZ_CP047696.1.
DR   AlphaFoldDB; F2JZJ5; -.
DR   STRING; 717774.Marme_0482; -.
DR   KEGG; mme:Marme_0482; -.
DR   PATRIC; fig|717774.3.peg.496; -.
DR   eggNOG; COG2200; Bacteria.
DR   HOGENOM; CLU_000445_131_3_6; -.
DR   OrthoDB; 675397at2; -.
DR   Proteomes; UP000001062; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071111; F:cyclic-guanylate-specific phosphodiesterase activity; IEA:UniProtKB-EC.
DR   CDD; cd01948; EAL; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   InterPro; IPR024744; CSS-motif_dom.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   Pfam; PF12792; CSS-motif; 1.
DR   Pfam; PF00563; EAL; 1.
DR   SMART; SM00052; EAL; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   PROSITE; PS50883; EAL; 1.
PE   4: Predicted;
KW   c-di-GMP {ECO:0000256|ARBA:ARBA00022636};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001062};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        17..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          260..516
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   530 AA;  59992 MW;  02FA9C6B2E29E1F0 CRC64;
     MGSVTGNSAI PTRVKRVLLV SFLFFIVIIY PSYVYYELQS SLQSKGVEVK QLLQSKINHM
     FDEMGLVLTL PELECDKHTV QALRRASFYS PYLTELGLFN SEYRVYCTDY GKSDFPIFRS
     IRSRIEAADD HRSMSIALSK SIKERALFAF LYDEKRQIGI NGLAPPHVLE NGIDGLLGDE
     FGYRIAVGLE VLGQHDLLKG STLIRPYESY IRSPDIFISV VVKDRHIVTT LLYRLPIALL
     VAILLYWSIC TGFKVRVAKQ ASFDNRVRKA ITNRDIDVYF QPIIDIKTSQ VSSAEALIRW
     QSERFGNVEP TRIVSVAAKY DLMNDLTTMI IRSVGAAYRN HKGVLDNISI FVNVDLATLC
     NDAFIDDLRD LFSLYPELEG RLGLETHGLY LLSELEYQTT VQLINTIRQF GIAISLDDFG
     LGYADTSVLK STSIDVLKLD RRFVSHFNRY DVANGDIVKQ ALVLANEKGI ELVAEGVETS
     NQMERLTSLG IRYIQGYHYN RALPEREFVK VAFKNTKEAN SSNTPNADTE
//