ID F2PY25_TRIEC Unreviewed; 2041 AA.
AC F2PY25;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Conidial pigment polyketide synthase PksP/Alb1 {ECO:0000313|EMBL:EGE06793.1};
GN ORFNames=TEQG_05787 {ECO:0000313|EMBL:EGE06793.1};
OS Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97) (Horse ringworm
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559882 {ECO:0000313|Proteomes:UP000009169};
RN [1] {ECO:0000313|Proteomes:UP000009169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4606 / CBS 127.97 {ECO:0000313|Proteomes:UP000009169};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
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DR EMBL; DS995751; EGE06793.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:TEQG_05787; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_6_0_1; -.
DR Proteomes; UP000009169; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF40; NORSOLORINIC ACID SYNTHASE STCA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 463..712
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1548..1626
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1654..1732
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 350..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1506..1550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1746..1765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2041 AA; 223150 MW; 0AA467AA1B28EDEB CRC64;
MVNQLHLYLF GDLTYDISTK LQPFLHSQSY PLLRSFFDCV CDKLRAEIGR LPAQDKEVFP
RFSSIAELLT WRSSHSRSNP AVENALTCIY QLGEFIHQHE GLGQEYFSPQ ETCVSGICTG
ALSAAAVSCC RTASELVPIA VQTVLVAFRL GMCTLRASKA IDPSEGNWSM VVSCDSTDKV
EELLCKFAET NNLPITSMPW ISAYGEDSWV SISAPASVLL ALRSSDILSG MRSRALDIHS
PYHAKHIFSK TDIDAILEKT DSQEWERYRA VRAVVSSTTG EVIEPEGLRS RLEAALTQIL
FEPIRWTQLT QGLAAFMSSI NATRFHVISI GTNAEATLIA SLSSKMQIEE AQAPGNGESA
KPDQHGGEAR GNMVRGRSKI AIVGLSGRYP SAENNEEFWD LIFRGLDVHK TVPDLHWSAK
THVDPTGKKK NTSATPYGCW LEHPEAFDDS FSTCRPARRP KLTLLSRDID TAIAGGTNIL
TNPDFTAGLD RGHFLSRTGN CRTFDDDADG YCRGEGVGTV ILKRLEDAIA DKDPIHGLIL
GTYTNHSAEA ESITRPHVGA QRDIMRNILS NSGVDPYSVS YVELHGTGTQ AGDAREMTSV
LDTFAPADAR RYRQPDESLH LGSVKSNIGH GEAAAGVSAL IKVLLMLRNN TIPPHCGIKN
KINSSFPTDL DARNVYIAKK AVSWPSREGQ PRRVFINNFS AAGGNSALVL EEKPAEAEIQ
GTDPRTAHVV TVSAKSAISL SRNIQSLADY IEKHQDEALF LPQLSYTTTA RRIHHQHRVA
VSGTSAADIK AALEKAAANG DGKVRARIAP KVTFTYTGQG AQYVGMAKQL YTLFDQFKGD
INRFDGLAQR LGFPSFLSVI EDESSEQLQD ISPVTLQLSS VCMQMALSRL LMSWNIIPDS
VIGHSLGEYA ALNIAGVLSD TDTIFLVGRR AQLLEQHCTL GTHSMLVVKA SLSAVQGALE
GAEFEVACIN APEETVLAGP NTQIEVLKES LNSNGFKTKI ISVPFAYHSS QVDSILGHFE
TVATGVRFRK PTIPVISPLL AEVIADEGII GPSYLRRHCR ETVNFLGALQ NVKETGFVKD
KAFFVDVGPH PIVTGMVKAT FGTSVTSMPT LQRSRDDQKV VTELLVSLYS AGTDLRWNEY
HRDFEASHKV LELPAYNWDL KNYWMQYVND WSLRKGDPPL IVGPSSLTST TIHKVLDDNV
DKIVVESDMA REDFNPLVQG HEVDGVPLCT PSVYADIALS IGKYLLERYH PEIETNLVDV
ANMTVLKALI ARAQGPQPLR TIATVDWPAK KASVSFRSYD KSGEPTVEHA TCEIRFTDRS
RLKLLESSTA AVKARMGTMR ETLGSGETQR FNRAMVYKMI SPLAQFHRDY QPLDEVIIDS
NSLEVSSQVN FKGVQAAGNF FAHPAYIDGL TQAGGFVMNC NDSNDLAVEV FVNHGWESLQ
LYEPLQKEKK YKTFCHMSPG DNRKFHGDVV VFDESERIVA SYKGIVFQGV PRRVLRFFLK
PEAPAAPRGQ ANQKTTARSA PVAPAATAMP TTTPKPIAKP TAAPATASPK SPKVKQAFQI
ISEEAGVPVE DLTDDCVFTD LGIDSLLALV ITSRFREELE LDGELDDIFL TYTSGKSLRG
YLAKQSGSDI PVVVEPTPLP VVAPKVEPAV ASRISIGADC AAALAIVSEE SGIAIAELAD
ECILAEIGID SLLALVIVSR FKEELDVDID SQSVFTDSFT IRDLKAFFGK GESTITTRAP
SILMESSDEN TMSSMTPPDS SSDYDTSEKL ERIAVPPATS VLLQGIARHA EKILFLFPDG
SGSATSYSAI PRLSPRVAVI GLNSPYNKIP ELFRCTLDDL IDSYIDEVRR RQPTGPYYFG
GWSAGGILAY RAAQKLIEAG EKVLDLVLID SPVPRGLDKL PQHFYDHCSK YQVFGHRAGP
TKGNGKAPAW LIPHFNATID TLHDYHASPL PAGKTPRTTI IWACESVIDG VNVPKLQSHP
DNTPGMKFLS EKRTDFSAAG WEAVFPGGDI ILKRMEHANH FSMMKGEHAG KLAGIIKATL
T
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