ID F2QD93_STROU Unreviewed; 572 AA.
AC F2QD93;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Phosphoglucomutase {ECO:0000256|ARBA:ARBA00039995};
DE EC=5.4.2.2 {ECO:0000256|ARBA:ARBA00012728};
DE AltName: Full=Alpha-phosphoglucomutase {ECO:0000256|ARBA:ARBA00041467};
DE AltName: Full=Glucose phosphomutase {ECO:0000256|ARBA:ARBA00041398};
GN Name=pgmA {ECO:0000313|EMBL:CBZ00611.1};
GN OrderedLocusNames=SOR_0952 {ECO:0000313|EMBL:CBZ00611.1};
OS Streptococcus oralis (strain Uo5).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=927666 {ECO:0000313|EMBL:CBZ00611.1, ECO:0000313|Proteomes:UP000008131};
RN [1] {ECO:0000313|EMBL:CBZ00611.1, ECO:0000313|Proteomes:UP000008131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Uo5 {ECO:0000313|EMBL:CBZ00611.1,
RC ECO:0000313|Proteomes:UP000008131};
RX PubMed=21460080; DOI=10.1128/JB.00321-11;
RA Reichmann P., Nuhn M., Denapaite D., Bruckner R., Henrich B., Maurer P.,
RA Rieger M., Klages S., Reinhard R., Hakenbeck R.;
RT "Genome of Streptococcus oralis strain Uo5.";
RL J. Bacteriol. 193:2888-2889(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate;
CC Xref=Rhea:RHEA:23536, ChEBI:CHEBI:58225, ChEBI:CHEBI:58601;
CC EC=5.4.2.2; Evidence={ECO:0000256|ARBA:ARBA00000443};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005164}.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the phosphohexose mutase family.
CC {ECO:0000256|ARBA:ARBA00010231, ECO:0000256|RuleBase:RU004326}.
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DR EMBL; FR720602; CBZ00611.1; -; Genomic_DNA.
DR RefSeq; WP_000222129.1; NC_015291.1.
DR AlphaFoldDB; F2QD93; -.
DR KEGG; sor:SOR_0952; -.
DR eggNOG; COG1109; Bacteria.
DR HOGENOM; CLU_016950_0_0_9; -.
DR Proteomes; UP000008131; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004614; F:phosphoglucomutase activity; IEA:RHEA.
DR GO; GO:0004615; F:phosphomannomutase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd05799; PGM2; 1.
DR Gene3D; 3.40.120.10; Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3; 3.
DR Gene3D; 3.30.310.50; Alpha-D-phosphohexomutase, C-terminal domain; 1.
DR InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
DR InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
DR InterPro; IPR005845; A-D-PHexomutase_a/b/a-II.
DR InterPro; IPR005846; A-D-PHexomutase_a/b/a-III.
DR InterPro; IPR005843; A-D-PHexomutase_C.
DR InterPro; IPR036900; A-D-PHexomutase_C_sf.
DR InterPro; IPR016066; A-D-PHexomutase_CS.
DR InterPro; IPR005841; Alpha-D-phosphohexomutase_SF.
DR PANTHER; PTHR45745:SF1; PHOSPHOGLUCOMUTASE 2A-RELATED; 1.
DR PANTHER; PTHR45745; PHOSPHOMANNOMUTASE 45A; 1.
DR Pfam; PF02878; PGM_PMM_I; 1.
DR Pfam; PF02879; PGM_PMM_II; 1.
DR Pfam; PF02880; PGM_PMM_III; 1.
DR Pfam; PF00408; PGM_PMM_IV; 1.
DR PRINTS; PR00509; PGMPMM.
DR SUPFAM; SSF55957; Phosphoglucomutase, C-terminal domain; 1.
DR SUPFAM; SSF53738; Phosphoglucomutase, first 3 domains; 3.
DR PROSITE; PS00710; PGM_PMM; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:CBZ00611.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU004326};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004326};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 41..179
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02878"
FT DOMAIN 226..311
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02879"
FT DOMAIN 325..451
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02880"
FT DOMAIN 504..547
FT /note="Alpha-D-phosphohexomutase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00408"
SQ SEQUENCE 572 AA; 62720 MW; 2482EB542AE21500 CRC64;
MTYQENYQKW VDFADLPDYL RQDLENMDEK TKEDAFYTNL EFGTAGMRGL IGAGTNRINI
YVVRQATEGL ARLIESKGGN EKERGVAIAY DSRHFSPEFA FESAAVLAKH DIKSYVFESL
RPTPELSFAV RHLNCFAGIM ITASHNPAPF NGYKVYGEDG GQMPPHDADA LTTYIRGIEN
PFAVEVADVE AEKASGLIEV IGEAVDAEYL KEVKDVNINP ALIEEFGTDM KIVYTPLHGT
GEMLARRALA QAGFDSVQVV EAQATADPDF STVKSPNPES QAAFALAEEL GRQVGADVLV
ATDPDADRVG VEVLQKDGSY LNLSGNQIGA IMAKYILEAH KNAGTLPENA ALCKSIVSTD
LVTKIAESYG ATMFNVLTGF KFIAEKIQEF EEKHNHTYMM GFEESFGYLI KPFVRDKDAI
QAVLVVAELA AYYRSRGLTL ADGIEEIYKE YGYFAEKTIS VTLSGVDGAE QIKEIMAKFR
NNAPKEWNTT AITIVEDFKA QTATAADGTV TNFTTPPSDV LKYTLADGSW IAVRPSGTEP
KIKFYIAVVG ESNEDSQAKI ANIEAEINAF VK
//
