ID F2R7K1_STRVP Unreviewed; 729 AA.
AC F2R7K1;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Putative drug exporters of the RND superfamily {ECO:0000313|EMBL:CCA56286.1};
GN OrderedLocusNames=SVEN_3000 {ECO:0000313|EMBL:CCA56286.1};
OS Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM
OS 4526 / NBRC 13096 / PD 04745).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=953739 {ECO:0000313|EMBL:CCA56286.1, ECO:0000313|Proteomes:UP000006854};
RN [1] {ECO:0000313|EMBL:CCA56286.1, ECO:0000313|Proteomes:UP000006854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 /
RC PD 04745 {ECO:0000313|Proteomes:UP000006854};
RX PubMed=21463507; DOI=10.1186/1471-2164-12-175;
RA Pullan S.T., Bibb M.J., Merrick M.;
RT "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae
RT provides new insights into global nitrogen regulation in actinomycetes.";
RL BMC Genomics 12:175-175(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FR845719; CCA56286.1; -; Genomic_DNA.
DR AlphaFoldDB; F2R7K1; -.
DR STRING; 953739.SVEN_3000; -.
DR KEGG; sve:SVEN_3000; -.
DR PATRIC; fig|953739.5.peg.5191; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_1_1_11; -.
DR Proteomes; UP000006854; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006854};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 209..341
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 729 AA; 75714 MW; F4F068E5935B634D CRC64;
MPCPTTKWEY APVATFLYKL GRSAFRRRRL VALLWVALLA VAGIGAATAP AATSSSFSIP
GTEAQRAFDL LEERFPGAGA DGATARVVFK APEGQKMTDP AHKAVVEETV AALRSGSDQI
VSVSDPYTAQ AVSQNGSTAY VSVAYKVNAM ELTDATREAL TDAGHDAQGK GLTVEVGGDA
LQTMPETGSG EIVGVVIAGI VLVLTFGSLV AAGLPLLTAI IGVGIGVSSI TALANVLDLG
STTSTLAMMI GLAVGIDYAL FIVSRYRAEL AEGREKEDAA GRAVGTAGSA VVFAGLTVVI
ALVGLAVVNI PMLTKMGFAA AGTVVIAVLI ALTLIPAMLG FAGDKVIGRK QRKGTAKKSD
KPNGGTRWAR FVIRRPVMVL LIGVLGLGAI ALPAASLEMG LPDDGVKPTS TTERRAYDAL
SDGFGPGFNG PLLVVVDGDK ATADRTVSTI KGLEGWAAVT PATPNKAGDA AMITVVPKDR
PSSGATETLV HDIRGATGDD VLVTGATAMN IDFSQKMNDA LVPYLALVVG LAFLLLTVVF
RSILVPLKAA LGFLLSVVAA LGAVVAVFQW GWLGSLFGVE QTGPIMSMMP IFMVGVVFGL
AMDYEVFLVT RMREAYVHGE RPGEAIVTGF RHSARVVTAA AVIMIAVFSG FIGMTDQMIK
MIGFGLAVAV LFDAFVVRMA IVPAVLALLG HKAWWLPKWL DRLLPNVDVE GEGLAETAPG
QAKPDLVKV
//
