ID F2SI95_TRIRC Unreviewed; 975 AA.
AC F2SI95;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Bromo domain-containing protein {ECO:0000259|PROSITE:PS50014};
GN ORFNames=TERG_01817 {ECO:0000313|EMBL:EGD85546.2};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD85546.2, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
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DR EMBL; GG700649; EGD85546.2; -; Genomic_DNA.
DR AlphaFoldDB; F2SI95; -.
DR STRING; 559305.F2SI95; -.
DR VEuPathDB; FungiDB:TERG_01817; -.
DR eggNOG; KOG0732; Eukaryota.
DR HOGENOM; CLU_000536_6_1_1; -.
DR InParanoid; F2SI95; -.
DR OMA; CIPSIRS; -.
DR OrthoDB; 2783776at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd05491; Bromo_TBP7_like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR045199; ATAD2-like.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23069; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23069:SF0; TAT-BINDING HOMOLOG 7; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000008864}.
FT DOMAIN 486..528
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 377..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 975 AA; 108104 MW; 7F83611D3984FF0F CRC64;
MDGMDGRGQV IVIGATNRPD SVDPALRRPG RFDREFYFPL PNVEARRAII DINTRGWEPA
LSDEFKDKLA ASTKGYGGAD LRALCTEAAL NAVQRVYPQI YQSKDKLLID PKKIKVSFKD
FMISLNKIVP SSERSASSGA SPLHSTIEPL LREPLREIQE RIAKLVPRRK ALTALEEAQF
EQPNDDVGFK REKLQEEFDR SRVFRPRLLI RGEYGMGQQY ITSALLNHFE GIHVQSFDLP
TLLSDSTRSP EAVVVQLFAE VKRNKPSVIC IPSIRSWYET LGNAVISTFM GLLRSIPPTD
PVLLLGILEG EADYEANSDI VRNLFGFSKK NQYFLSYPEL SQRREFFQPI IDFIRTPPAD
FPEPDNRKKR VIEQLELAPP APPKPPPAPT KEELKAQKRK DRQTLNLMKI RIQPIMDQIR
KYKRFRTGVV DESQIRYLYD DDDPNVVTSD LPPQQRSTFR PYEKDTDKAG VPGLREVASG
KFYYNLDIVT IEKRLSNGYY KRPKDFLADI KRLAKDAKQL GDPDRQLKAN ELLANVEVDI
GAIDNTDPAL VAECEVVYTR ELEREKAALE KIKQPVADAD GTMKPPAGPP PQMNIAHGSI
ELSNVSSAGP VVLGELFNSP CPAPGSKSGP GHPSLTNGHT PGFHLHGGVD GVRPPTSNGP
LHKPEGDGDV EMSNSDHTSG AHQNNTQNSS FGPSAQPRPL HSYTAPSQFM RHQSGLSTLS
QKGNITPMAP GSQPGDYVND ASTTQTTSDK KNSGPTDIMH TNPHASLIGS AMHDAPDLTL
YPDRASGDEH LPETQQGDSS WISSQMTPLR GVAEFIHSQS TSNANGSQSQ PRHSQASQPH
PVGPPPLFDA ASSRSSGGNT HGNPVTPPSR NGETTRISNL INSEPKQPEP PLPNLIVDED
LNRELHDELS TKTGGFSVEQ LEQINTELMD CLWVNRNEWN RQEVAMILRS TFLETLDDIK
SSQNYVDTTQ KLGRQ
//
