ID F2SJ72_TRIRC Unreviewed; 190 AA.
AC F2SJ72;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Endosomal/vacuolar adapter protein YPT35 {ECO:0000256|ARBA:ARBA00033774};
DE AltName: Full=PX domain-containing protein YPT35 {ECO:0000256|ARBA:ARBA00033785};
GN ORFNames=TERG_02056 {ECO:0000313|EMBL:EGD85785.1};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD85785.1, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Recruits the lipid transfer protein VPS13 to endosomal and
CC vacuolar membranes. {ECO:0000256|ARBA:ARBA00033728}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000256|ARBA:ARBA00004148};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004148}.
CC -!- SIMILARITY: Belongs to the YPT35 family.
CC {ECO:0000256|ARBA:ARBA00007426}.
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DR EMBL; GG700649; EGD85785.1; -; Genomic_DNA.
DR RefSeq; XP_003237334.1; XM_003237286.1.
DR AlphaFoldDB; F2SJ72; -.
DR STRING; 559305.F2SJ72; -.
DR GeneID; 10378712; -.
DR VEuPathDB; FungiDB:TERG_02056; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_070610_0_1_1; -.
DR InParanoid; F2SJ72; -.
DR OMA; LAYFLNC; -.
DR OrthoDB; 2041724at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR CDD; cd07280; PX_YPT35; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037917; Ypt35_PX.
DR PANTHER; PTHR10555:SF170; FI18122P1; 1.
DR PANTHER; PTHR10555; SORTING NEXIN; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT DOMAIN 77..190
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 190 AA; 20943 MW; 035A4713B44E1808 CRC64;
MLPQPLHVDS IGAETASAPR AGTPQSNPQT ATPPYWKHSR NISHASHTSL DRSSGLITLE
DHSEDPSCDK SKGLWAKNVT IDNYAVVKGQ SGIGAYVVWI CNIQTLEGAS MVVRMRYSQF
VDLRCKLAEA YPHCKKSLPV LPPKSALFKF NAKFLETRRQ GLAYFLNCVL LNPEFSGSPI
LKNTLFTHSA
//
