ID F2SQH7_TRIRC Unreviewed; 700 AA.
AC F2SQH7;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Origin recognition complex subunit 4 {ECO:0000256|ARBA:ARBA00019083};
GN ORFNames=TERG_04842 {ECO:0000313|EMBL:EGD88595.1};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD88595.1, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ORC4 family.
CC {ECO:0000256|ARBA:ARBA00005334}.
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DR EMBL; GG700652; EGD88595.1; -; Genomic_DNA.
DR RefSeq; XP_003234248.1; XM_003234200.1.
DR AlphaFoldDB; F2SQH7; -.
DR STRING; 559305.F2SQH7; -.
DR GeneID; 10372801; -.
DR VEuPathDB; FungiDB:TERG_04842; -.
DR eggNOG; KOG2228; Eukaryota.
DR HOGENOM; CLU_007115_3_0_1; -.
DR InParanoid; F2SQH7; -.
DR OMA; MWRQLGR; -.
DR OrthoDB; 230201at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR016527; ORC4.
DR InterPro; IPR032705; ORC4_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF14629; ORC4_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864}.
FT DOMAIN 281..454
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 76375 MW; DDC5DF245D7F6584 CRC64;
MESDSRPSKR RRVFNPDLDP EPERGECPSP TRTRKTRKNT KHVTEPKSAA NAGTEEAAEK
KNDEALSQST RRSARIRVTG NSVVSTSAGP PRPRVVEEED TQISKRDRKA KTSIAGSSST
KKLARKLSKP ASATTTTTKT TTGRKGKKED KKDERDGRLK GKKEKEGVSG TDDVWEVPCD
RENEDEDELA IAQLVANDAA MQLQAELGER TEEPPERVNQ PAYAEKFLTL CEEHGLEPML
APLGEFILEK LNGKRLIPLK GLDNEYRTVF QLLEQTVVAG EGNSLLLLGA RGSGKTAVVN
TALAALSKTN ADDFHIVRLN GFLHTDDKVA LREIWQQLGR EIDPQEDLEK PSSYADTMAS
LLALLSHPEE ITGPLPEENG MTTTKSVVIV LDEFDLFSYH PRQTLLYNLF DIAQAKKAPV
AVLGLTTKVE ATENLEKRVK SRFSHRHVFL PRPRSFVEFV DICMASLKVE GDEVDSCPLD
GEKGPILLKG WNSYIQDLFE DAEFAGHLEP IYYRSKSVRD FFRSALVPIT SMALGSVTGT
KAELPSTQSF ASNSLACPDP APLPFTQLSG STSNVSLPLS LLLTATRLTA LHESMATATA
TAASLSLSFA AVYSEYVRLL TAAKASASAS GAAATPGRVW GKEAAKEAWE KLVEWGLVLP
VNGYGMGDGK MFRVEVSFEE AVAALGSTGA GALGRWWRDG
//
