ID F2SVV9_TRIRC Unreviewed; 838 AA.
AC F2SVV9;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DUF221 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=TERG_06680 {ECO:0000313|EMBL:EGD90453.1};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD90453.1, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; GG700655; EGD90453.1; -; Genomic_DNA.
DR RefSeq; XP_003232689.1; XM_003232641.1.
DR AlphaFoldDB; F2SVV9; -.
DR STRING; 559305.F2SVV9; -.
DR GeneID; 10374186; -.
DR VEuPathDB; FungiDB:TERG_06680; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_0_0_1; -.
DR InParanoid; F2SVV9; -.
DR OMA; QGIGMFP; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 41..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 718..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..196
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 217..420
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 432..709
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 838 AA; 95527 MW; 97F45F50B80AE4F9 CRC64;
MTSRPPSLLA ATTTSALVYA FGTDQPDGPR YQDQTRGQRD LLTQIVISVS FGLSAFITFC
FLRPKWSALY AARRKTRTAA SRLPDLPDSL FGWIPVLFKI SDEEVLASGG LDAFVFLLFY
KYSIHFLSIV FFFSVVVILP VRYSYTGERG YPWDGDRGDK PAGDSDKKQK TDPTFLWLYV
VFSYVFTGVA VHLLIRYTNR VIQIRQKCLG GQTTMADRTI RLSGIPVDLR SEDKIRGFIE
GLEIGNVESV MLCRDWRELD RLMEGRKRTL QRLEESWAKY LRYRKSKPGG VASRTNRIAP
QIDTDDTAED ARLLSDEPNT HQNYILENPG ARPRTRIWFG PLKIQFKSID AIDYYEEKLR
QLDEKIEIAR QQECTPGALA FVTMESIAAC QMAVQAILDP WPMQLVANLA PAPADVVWQH
TYLSRAERMI RGWTITTVIC VLTVFWSLLL VPLAYLLNLE TLEKVIPRLA EILSEHPLLR
SLMQTGLPTL TLSLLSLAVP YIYDWLANVQ GMTSQGDVEL SVISKNFFFT FFNLFLVFTV
FATASNFYGL WENLRDVFKD TTTIAFALAR SLEKLAPFYT NLIVLQGLGL FPFRLLEFGS
VFLYPFQRMF AVTPRDYADL RKPPIFSYGF ALPPTILIFI VCLVYSVFPS SWLVCLFGLI
YFSIGQFIYK YQLLYAMDHQ QHSTGRAWPM ICSRIILGLV VFQLTMIGSL ALRSAITRSI
LIVPLLAATV WFSYFFTRTY EPLMKFIALR SIDRSRDADS NLSPTPSSNF SPPSQWDRDA
IPLRLRGRDI APRLRKYINP NLVIPLDPAW IPGQPENYDN DFASFSQNGI SVPNQEAV
//
