ID   F2T9U0_AJEDA            Unreviewed;       667 AA.
AC   F2T9U0;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 2.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Beta-galactosidase {ECO:0000313|EMBL:EGE80003.2};
GN   ORFNames=BDDG_02944 {ECO:0000313|EMBL:EGE80003.2};
OS   Ajellomyces dermatitidis (strain ATCC 18188 / CBS 674.68) (Blastomyces
OS   dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=653446 {ECO:0000313|EMBL:EGE80003.2};
RN   [1] {ECO:0000313|EMBL:EGE80003.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18188 {ECO:0000313|EMBL:EGE80003.2};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease.;
RA   Cuomo C., Klein B., Sullivan T., Heitman J., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A.M., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA   Birren B.;
RT   "Annotation of Blastomyces dermatitidis strain ATCC 18188.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
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DR   EMBL; GG749417; EGE80003.2; -; Genomic_DNA.
DR   AlphaFoldDB; F2T9U0; -.
DR   HOGENOM; CLU_005732_2_0_1; -.
DR   Proteomes; UP000007802; Unassembled WGS sequence.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.102.20.10; Beta-galactosidase, domain 2; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR018954; Betagal_dom2.
DR   InterPro; IPR037110; Betagal_dom2_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421:SF122; BETA-GALACTOSIDASE A-RELATED; 1.
DR   PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR   Pfam; PF10435; BetaGal_dom2; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SMART; SM01029; BetaGal_dom2; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..667
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005346482"
FT   DOMAIN          357..512
FT                   /note="Beta-galactosidase"
FT                   /evidence="ECO:0000259|SMART:SM01029"
SQ   SEQUENCE   667 AA;  74201 MW;  DD9866AC5B93BC9A CRC64;
     MRFLSACAIA CLALQSAAVV VVDRKLGGFT VIEHPDPAKR DLLQDIVKWD NESLFINGER
     IMIFSAEFHP FRYSFMGLII RCGLPVPSLW LDIFQKIKAL GFNCVSFYTN WALTEGKPGE
     YTAEGIFAWE PFFEAATEAG IYLLARPGPC INAEVSGGGF PGWLQRVRGQ FRTSDKDYLA
     ATDNYIAHIA SPVAKAQITN GGPVILYQPE NEHTLSLRIH DFPDGDYMQY VIDQARKAGI
     VVPMISNDAW AAGNNAPGTG KGEVDIYGHD KYPPIPTSSL LDFCPPIGGS STSSKVPSHL
     TPLSSFGNVF LNLYMGHPGG YTSYDYGAPI SEDRNITREK YGELKLIGNF MKASPSFMNA
     VPGHWSISKF TTTPTLTVTS LIGRLSDSSF FVLRHSEYSS KASTNYKLKL PTSVGRLIMP
     QLNGTLTLNG RDSKIHVTDY DVAGTKYFLF DCRDIHMEEV WGPQGLLVEG PSHDMTIKKV
     DDYVVLNWET MRERRIVDIG DLSVFILDLE SLELRRASPL RRKAVLGLGI QHGSMGVTLD
     PGRARAILGA SSTNIYSFPK LKAGEKYVFT MLVDNMSLGQ DYVIGADSTK NPRGIQHYKL
     FGRLQSRVTW KLAGNLGGED YQDRFRGPLN EGGLYIERQG WHQPNPPHPV LEVCKPHYRR
     RCGWVRE
//