ID F2TX50_SALR5 Unreviewed; 873 AA.
AC F2TX50;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=PTSG_00667 {ECO:0000313|EMBL:EGD75959.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; GL832956; EGD75959.1; -; Genomic_DNA.
DR RefSeq; XP_004998135.1; XM_004998078.1.
DR AlphaFoldDB; F2TX50; -.
DR STRING; 946362.F2TX50; -.
DR EnsemblProtists; EGD75959; EGD75959; PTSG_00667.
DR GeneID; 16078731; -.
DR KEGG; sre:PTSG_00667; -.
DR eggNOG; KOG4171; Eukaryota.
DR InParanoid; F2TX50; -.
DR OrthoDB; 2898719at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF13; SOLUBLE GUANYLATE CYCLASE GCY-35-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799}.
FT DOMAIN 506..634
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 286..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 451..481
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 305..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..752
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 873 AA; 95131 MW; C02201FDB8B68EBD CRC64;
MYGFVEEALN AYVLSLPDGK EKLDLIRREA NVTHTAVNFH HAYSDEHTLN MVVSAAKVLG
IDAEECLSQI GFFQVGVLVE KGYLPLVQSL GDNFYELLLH LDSMHLNIVN AYPSMKGPSF
KPHRQKDGSL LLHYYSSRMG IYPYAIALLK DIAKKVYSLD IELKHVKKKG QDHDHDVFHI
FMGPEGYGEK EYFDSEKAHA ISGQLTFGPS MVDSVFPWHI SFDRTFTITS VGPRLKERLP
AGGVGQPFFR LMRVVRPDIR GLGFDSLLES FDHSPLLVQA CAVPPGSDAS TAPPSGCPFA
AAAARTTGSA TTPKPNQTRR RRGNSVSQST SAGSSSTSSS SSNSDTAEAN KNKSAQGSGV
NDDTALPGVF PDDGGKDPIS GITILKDGLF LKGELVFSPE HDAMLFLCIP TISSLEEMEK
LDICLEDIPI HSNGRELVIS TAHQSATVLM AQTLQNTTAS LDKAMEDLDK EKERVDGLLH
SILPTQVAQA LKAGEIPEPE HYEAVSILFS DIVSFTKISS SVPVREVMDM LNELFSKFDA
LCTKHGVYKV ETIGDAYMVA SGLPKADPRH ADVIAAFAVE MVAAAETVIS PMDGEPINIR
VGMHSGRIMA GVVGRERPRY CLFGDTVNVA SRMESTGVGG AVQVSYAFIK ALPNKDDWNI
LKRGTVPVKG KGEMKTFFVL GRAGSSMQLA PPDASDYESE AQTPRIAFGH AGSDPRSPAS
YGFMPQPQHQ QQPVPASPAP QARQLPPPPK PDTMFEVVVH GSDIDIKLPY VPSSMTLGEL
MLEIHPEGTR DNADSDYRFY LDDMHEGMLL PRLTVEQLYA SLVTNKVIES GSRQLSLYAE
TRTCLKHPFA TPRIQTRAPS IPNIAVAPSN EFI
//
