ID F2UD95_SALR5 Unreviewed; 2245 AA.
AC F2UD95;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|Pfam:PF05729};
GN ORFNames=PTSG_05955 {ECO:0000313|EMBL:EGD74590.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832969; EGD74590.1; -; Genomic_DNA.
DR RefSeq; XP_004992847.1; XM_004992790.1.
DR STRING; 946362.F2UD95; -.
DR EnsemblProtists; EGD74590; EGD74590; PTSG_05955.
DR GeneID; 16073420; -.
DR KEGG; sre:PTSG_05955; -.
DR eggNOG; KOG0266; Eukaryota.
DR InParanoid; F2UD95; -.
DR OMA; EYCHIRE; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR Gene3D; 2.160.20.80; E3 ubiquitin-protein ligase SopA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR001646; 5peptide_repeat.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22847; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF00805; Pentapeptide; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF141571; Pentapeptide repeat-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 1030..1119
FT /note="NACHT"
FT /evidence="ECO:0000259|Pfam:PF05729"
FT REPEAT 1711..1752
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2245 AA; 245223 MW; A14BC1D941F97281 CRC64;
MGSGSSSLRR RRKRGAGDEK QQQKQQQKQQ KQQKQQKQQK SRRAGKATKA AGASAATPAW
IGSKTAGFAF EEPPRAAQID FTLDDSDLQR VSGLLTDTWR SDVLDRADAG TEELGADQVK
ALFKKQQLRI ELDNAVGALR ALAQQQGLKE RTVFVSHAWP GSPEEEPFME DVISFTDTLR
LAGLHVSSAM LAWRDADKAY PDFIREHLKS CDAIVLAASP SFKSEYTREG SGVHADAAAA
EELSLDPLPV VLAGGFMDSL PGSLTKVLAS VCSDTVEYCK LLPAVVANLL GLAADTTAQD
LIAKHVATVE TKVATLEETT IPADDIPTIT ASYEEERQRL DLRAFVLKSS LTRSQRRFLD
NGLQQQVDAI GQVAVKRMRS SAAAAAAAGG GGGEGGSGGK AGTDVLTKDH KGQDGPHLSE
QYTAFMTGDR AILLVVGDSD LLSTAEDMLV SRQWQYYDAN HAMIPVVIDL EQAAVPTSRV
VEQALVKHGY TAAEVEALRE GHPGLVLFFK NWRAADHCTN IYVQNELDHW GSLHGSAPKV
VFLVDKAEVQ AALTPETKGE APATGGVAGA AASVDQWKLP PVLHPRLLGA DVEGPIVLYF
LPCDMAGEPM PTAFQMLLLS GRADTPPPAL PSVTFAEAKA PTATATQGKG KAEESKEEES
VVDLDAIKER CLDSLHKTYL KAREDLVRKQ LASELAELFR AMNRVTKLTT NRHKGFISYS
WPRDRSDQQK LQGRLSRLRR DMARIGLDVS LDIMDLKPGM DIDEFMRKGI DKSTAVFLIG
TPDYNRRVPE PTNKVEADKV NDGDVTNVGK EYCFIRQAAS ERGVLVFPLW FDRGEHVTPA
SAFPDAFLNY PFQPVRDCSS YRYYLAALPA LLNTIIPIFV DGDVPDEERQ RWNKACDKFL
TSLHGVEQST STKAVWEWFF QDIKERERRE QEFQESLKQF FTNTPAEILE QLSGSRDSAA
AALEANIARI RQATDVLKPE SPVQQQLKQF VRVKASKTAA PKKEEEKFDL VDNVLQAVAA
EDANTKPLYL LVQGGTGSGK SAFIRYLEFR LWADRDKDPS CPVPLYVPLA QTNNAETDLM
SETLMSIGLD EAGIEQLKRE ASFVVLLDGF DELGKPVNLY RSNKLDEWQA HVVVGARSQF
LQSLPEYQSL FTHATQSRVD ERYILPFDQT QIEAFLERFV RGPDAQGQDA HTLHDQLSNI
GGLWDLLSTP FLLHMACLCL PILESGMVPS KGLPRNISKR HLYESFVSLM HGREMWRCVT
RRRVPIDVNL HVALLAFDQD LARSLFLGHS ITAKLIRAEA VSDAALKIAV DGSPLRVVGV
GPRVTFVHKS VLEYLAACAL MSDVVSLAEG EVVPILGTRL VRNEPGLVEF AGQIVRADKE
AQTRLMHVIE LSKTQPHATI AAGNAATILN CARVPFSGLD LSGARLCGAD MRAALLHRTN
LTGADLRGVF FAEAIMTGAC LDMCNMRDVE FGQLPDVDEQ KDRVDLLHVT GDGPSARPMT
VTRGKHINYW RTETTKGDDG SDEVAIRLLS TAPLPQDVPH GDNRFLPITF SSCRAALGTM
PSDQQVDIGP VPGMEDALAI LPWTIKTDSP IVVGTGWPFR NTIRICDGGE KAAMVLRDNT
LAIYARDGSG SAKRIVKADV YRDLEALGVN MHHKGEIDFV KCELSPNGRY AVVFVHPLSI
FGYEGEGDVE LPGPMYLYDL AAPEGTAPRL LRHHNLWVAC VSFLKNSTQF LSLSLDKTMC
TWDLEKGEVI STIRNVNSGE HHPNLLVVSP KEKYCVTVDD THGWSWSPHS CASLWRLSDG
VRVARLVGHD VGKLGAVAFS ADESLVATAG GAKTVCVYET GEGTLQVVLR GHVGGISHVQ
FLSNSNLLST SGKSMKLWSL AQANALPAIT YTPNATEVTA SEGCWCVQTV SDYVVGTHNV
HPRRLGVWNR HTGELMPSLN GSYMDGTTRG LATAKDDKSV YIGLNSSGCL PIPRVDVEKG
GAVVQELEVL RRWSPTHFHG NTLAISADFR FMVATTLWRT SLLYDLEQGK LLGTLDGHTH
DHVWNAMLSP SGKYAATTAS DGKLIVFDVS TRKPTCNLPS KDIEFGFNCK DQLVVVEKGS
KTVKTYDVSG ASPAEVGAAN TSFASADQLG MAYVCSRTHA VLCERNGTTL TLRNIDNFEV
EAVVESFFSG LGTPIISQDW KQLLCQKTGL AGLDVYGLDK GGSKLQWVTR PTFVTNSSTS
VVGCVGLPSA ARQLLAQLGA KMAAE
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