ID F2UN51_SALR5 Unreviewed; 1089 AA.
AC F2UN51;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=PTSG_09242 {ECO:0000313|EMBL:EGD78550.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832983; EGD78550.1; -; Genomic_DNA.
DR RefSeq; XP_004989499.1; XM_004989442.1.
DR AlphaFoldDB; F2UN51; -.
DR STRING; 946362.F2UN51; -.
DR EnsemblProtists; EGD78550; EGD78550; PTSG_09242.
DR GeneID; 16070048; -.
DR KEGG; sre:PTSG_09242; -.
DR eggNOG; KOG1587; Eukaryota.
DR InParanoid; F2UN51; -.
DR OMA; SCCWANE; -.
DR OrthoDB; 5474766at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12442:SF5; DYNEIN AXONEMAL INTERMEDIATE CHAIN 3; 1.
DR PANTHER; PTHR12442; DYNEIN INTERMEDIATE CHAIN; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 898..941
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1089 AA; 117842 MW; DB0B0C9B00B55248 CRC64;
MADNEEAASA AATSPTNEET TQQKKKQSKA ASKAGSKAAS RAASAKPKSP GDDGKEAKEK
QAEPAATEGQ SAADQAEAQG QDQQQQQGQE KGAEAPATAE GEAAEATTGD AATDDAASSS
QPQEQGQRVT SAGAGAGTGT PTVATLYADG GLPEGALGMF LTGATQEIFG CIADENVTAE
KPTFLIPIEK IKEDFLNRAA VSDFSVCKEQ IQAYDGEELL VVYDPDFTFE TNFIVCLTEQ
AKGDYYQRVA AVVQKAEEER KKKQAGGDGG EEWSEDMEGV PMPTKKKRRP PAPWVSLGSE
HEVDDAKCTP SRPPICLLVS RKRRLFGAPR TFHDAIFDSE HEFPPNTEYK SQPPIEDAPP
PLHRRLMDAG AQAIPDTAHT TTQTTWYAHR NASTQWRPRT TADAAAGPDG ADDDGIPRTD
DDYRQMAKAI ETAYGRIRPF LLQNSVINVH VDDFLHLRGD KLVALGTKAD SALKEFQSFK
FMNFGNSRVV SSVDWHPTES GVIAVAYSKP VTLQERVTSE KPNEKSRILV WGLSDPIQPK
IILEAPDDVL SVKFCPTHPN IVVAGCFNGQ LAVFDLGKQG RRLNSGSVRS SDSSGSQEIV
LRHVALSEID DGHRAPITDV QWLPHVCDVS ASGAMTQEDM PPAHTYQLMS CAADGTCLIW
DVRGEDKLPS INLKALDLVW KPLVKVYLSS DAAGEVMASK FALYTTHRDF VAERAPDLSM
TTELCVATEQ GQLHFLDWRR PETDSGKLGV QQIRTTVDAH GGACTSVARS PFFPALLLSV
GGSSISLWHD KSSTPILTHR LPCMARPVAG CWSLHRPGVF FIARADGSVD VWDFLDTSYK
PSLTQSICAP TSLTTLAAGE ISTSSSRGRL FFLAAGDVNG STHIIDLPKT LIHPVANERV
LRYPLLLKEL VKLTAAEDPR LEALQSALST TQDVAKHVNE CKHDIENYAI VQRLEHTLKD
YVVGTSGCVP LVDHGRLLID GDVKLRLESD GRAARRYIFL FQRVMLVVQV LSSLRATNDD
DSEGQGGAGG VGATMQAGGD VTLVVPGGDA AADHKRELRA VYEEFKKTEK DFLVQVGLRT
EGDEEEDMA
//
